ArticleAnnals of translational medicine2020
Test-retest variability of brain morphometry analysis: an investigation of sequence and coil effects.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- No reliable gray matter alterations in idiopathic dystonia.Frontiers in neurology · 2025Pooled it
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- Cortical Thickness in Migraine: A Coordinate-Based Meta-Analysis.Frontiers in neuroscience · 2020Pooled it
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- Implementing ABCD studyMethodsX · 2024Article
- A comprehensive protocol for quantitative magnetic resonance imaging of the brain at 3 Tesla.PloS one · 2024Article
- Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study.European journal of hybrid imaging · 2023Article
- Multisite test-retest reliability and compatibility of brain metrics derived from FreeSurfer versions 7.1, 6.0, and 5.3.Human brain mapping · 2023Article
- The Unresolved Methodological Challenge of Detecting Neuroplastic Changes in Astronauts.Life (Basel, Switzerland) · 2023Article
- Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Test-retest reliability of FreeSurfer-derived volume, area and cortical thickness from MPRAGE and MP2RAGE brain MRI images.Neuroimage. Reports · 2022Article
- Article
- Improving segmentation reliability of multi-scanner brain images using a generative adversarial network.Quantitative imaging in medicine and surgery · 2022Article
- Quantitative comparison of subcortical and ventricular volumetry derived from MPRAGE and MP2RAGE images using different brain morphometry software.Magma (New York, N.Y.) · 2021Article
- Normal volumetric and T1 relaxation time values at 1.5 T in segmented pediatric brain MRI using a MP2RAGE acquisition.European radiology · 2021Article
- Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.PloS one · 2021Article
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9 authors.
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Abstract
backgroundPrecise and reliable brain morphometry analysis is critical for clinical and research purposes. The magnetization-prepared rapid gradient echo (MPRAGE), multi-echo MPRAGE (MEMPRAGE) and magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) sequences have all been used to acquire brain structural images, but it is unclear which of these sequences is the most suitable for brain morphometry and whether the number of coil channels (20 or 32) affects scan precision. This study aimed to assess the impact of T1-weighted image acquisition variables (sequence and head coil) on the repeatability of resultant automated volumetric measurements.
methodsTwenty-four healthy volunteers underwent back-to-back scanning protocols with three sequences and two different coils (i.e., six scanning conditions in total) presented in a randomized order in a single session. MorphoBox prototype and FreeSurfer were used for brain segmentation. Brain structures were divided into cortical and subcortical regions for more precise analysis. The acquired volume and thickness values were used to calculate test-retest variability (TRV) values. TRV values from the six different combinations were compared for total brain structures, total cortical structures, total subcortical structures, and every single structure.
resultsThe median TRV value for all brain regions was 1.23% with MorphoBox and 3.14% with FreeSurfer. When using FreeSurfer results to compare the six combinations, for total brain structures volume and total cortical structures volume and thickness, the MEMPRAGE-32 channel combination showed significantly lower TRV values than the others (P<0.01). Similar results were observed with MorphoBox. For total subcortical structures, the MP2RAGE-32 channel combination showed the lowest TRV values with both MorphoBox (lower about 0.01% to 0.17%) and FreeSurfer analyses (lower about 0.02% to 0.37%).
conclusionsTRV values were generally low, indicating generally high reliability for every region. The MEMPRAGE sequence was the most reliable of the three sequences for total brain structures and cortical structures. However, MP2RAGE was the most reliable for subcortical structures. The 32-channel coil showed better repeatability results than the 20-channel coil.
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