ArticleChemical science2019
Functionalized DNA nanostructures as scaffolds for guided mineralization.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- DNA-Based Hydrogels for Musculoskeletal Reconstruction: Harnessing Dynamic Programmability and Multimodal Therapeutic Integration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Programmable DNA-based biomaterials for bone tissue engineering.Fundamental research · 2025Review
- DNA-based hydrogels for bone regeneration: A promising tool for bone organoids.Materials today. Bio · 2025Review
- Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications.Journal of nanobiotechnology · 2025Review
- DNA hydrogels for bone regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Secondary Structure of DNA Aptamer Influences Biomimetic Mineralization of Calcium Carbonate.ACS applied materials & interfaces · 2023Article
- Dynamic RNA synthetic biology: new principles, practices and potential.RNA biology · 2023Review
- Prospects and challenges of dynamic DNA nanostructures in biomedical applications.Bone research · 2022Review
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Uniaxial Hydroxyapatite Growth on a Self-Assembled Protein Scaffold.International journal of molecular sciences · 2021Article
- DNA nanostructures as templates for biomineralization.Nature reviews. Chemistry · 2021Review
- Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions.Nature reviews. Chemistry · 2021Review
- Two-in-one strategy: a remineralizing and anti-adhesive coating against demineralized enamel.International journal of oral science · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of DNA nanotechnology uses synthetic DNA strands as building blocks for designing complex shapes in one-, two- and three-dimensions. Here, we investigate whether DNA nanostructures are feasible platforms for the precise organization of polyaspartic acid (pAsp), a known mineral carrier, with a goal towards biomimetic mineralization for enamel regeneration. We describe the preparation of DNA-pAsp conjugates and their subsequent assembly into ordered nanostructures. Covalent attachment of pAsp to DNA was noted to hinder DNA nanostructure formation past a certain threshold (50% pAsp) when tested on a previously published DNA system. However, a simplified double stranded DNA system (3sDH system) was more robust and efficient in its pAsp incorporation. In addition, the 3sDH system was successful in organizing mineral inducing groups in one dimension at repeating intervals of 28.7 ± 4.0 nm, as determined by atomic force microscopy. Our results demonstrate that DNA nanostructures can be functionalized with pAsp and act as a platform to investigate guided mineralization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.