Evidence map›Paper›PMID 32055363›Full record

ArticleChemical science2019

Rhodium(i)-catalyzed C6-selective C-H alkenylation and polyenylation of 2-pyridones with alkenyl and conjugated polyenyl carboxylic acids.

Haoqiang Zhao, Xin Xu, Zhenli Luo, Lei Cao, Bohan Li, Huanrong Li, Lijin Xu, Qinghua Fan, Patrick J Walsh

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 58 citations in OpenAlex.

  1. Crystal structure of 4-bromo-cinnamic anhydride.Acta crystallographica. Section E, Crystallographic communications · 2025
    Article
  2. Article
  3. Rhodium-Catalyzed C(spOrganic letters · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Haoqiang ZhaoDepartment of Chemistry , Renmin University of China , Beijing 100872 , China . Email: 20050062@ruc.edu.cn.
Xin XuDepartment of Chemistry , Renmin University of China , Beijing 100872 , China . Email: 20050062@ruc.edu.cn.
Zhenli LuoDepartment of Chemistry , Renmin University of China , Beijing 100872 , China . Email: 20050062@ruc.edu.cn.
Lei CaoDepartment of Chemistry , Renmin University of China , Beijing 100872 , China . Email: 20050062@ruc.edu.cn.
Bohan LiDepartment of Chemistry , Renmin University of China , Beijing 100872 , China . Email: 20050062@ruc.edu.cn.
Huanrong LiDepartment of Chemistry , Renmin University of China , Beijing 100872 , China . Email: 20050062@ruc.edu.cn.
Lijin XuDepartment of Chemistry , Renmin University of China , Beijing 100872 , China . Email: 20050062@ruc.edu.cn.ORCID 0000-0003-4067-8898
Qinghua FanBeijing National Laboratory for Molecular Sciences and Institute of Chemistry , Chinese Academy of Sciences , Beijing , 100190 , China . Email: fanqh@iccas.ac.cn.ORCID 0000-0001-9675-2239
Patrick J WalshRoy and Diana Vagelos Laboratories , Penn/Merck Laboratory for High-Throughput Experimentation , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: pwalsh@sas.upenn.edu.ORCID 0000-0001-8392-4150
Renmin University of China · CNChinese Academy of Sciences · CNCalifornia University of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A versatile Rh(i)-catalyzed C6-selective decarbonylative C-H alkenylation of 2-pyridones with readily available, and inexpensive alkenyl carboxylic acids has been developed. This directed dehydrogenative cross-coupling reaction affords 6-alkenylated 2-pyridones that would otherwise be difficult to access using conventional C-H functionalization protocols. The reaction occurs with high efficiency and is tolerant of a broad range of functional groups. A wide scope of alkenyl carboxylic acids, including challenging conjugated polyene carboxylic acids, are amenable to this transformation and no addition of external oxidant is required. Mechanistic studies revealed that (1) Boc

Identifiers

PMID32055363
PMCPMC6991184
OpenAlexW2973202931

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.