ArticleChemical science2019
Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 110 citations in OpenAlex.
- Lysosome-Targeted Squaramide Anion Transporters.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Lipophilic mono-guanidinesRSC advances · 2026Article
- An increased throughput workflow to identify ion transport and membrane lysis agents for antimicrobial discovery.Chemical science · 2026Article
- Flipper dendrimers.Chemical science · 2026Article
- Chlorination-Enhanced HChemistry, an Asian journal · 2026Article
- Hemi-Indigiosin: A pH and Red-Light Responsive Transmembrane HCl Transporter.Angewandte Chemie (International ed. in English) · 2025Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Chloride Selective, Nonprotonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.Angewandte Chemie (International ed. in English) · 2025Article
- Activity Control of a Synthetic Transporter by Photodynamic Modulation of Membrane Mobility and Incorporation.Journal of the American Chemical Society · 2024Article
- Photoswitchable Bis(amidopyrroles): Modulating Anion Transport Activity Independent of Binding Affinity.The Journal of organic chemistry · 2023Article
- Article
- Halogen bonding relay and mobile anion transporters with kinetically controlled chloride selectivity.Chemical science · 2023Article
- Fluorinated tetrapodal anion transporters.iScience · 2023Article
- Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores.Journal of the American Chemical Society · 2023Article
- Chloride Binding Modulated by Anion Receptors Bearing Tetrazine and Urea.Chemphyschem : a European journal of chemical physics and physical chemistry · 2023Article
- Transmembrane Transport of Bicarbonate by Anion Receptors.ChemPlusChem · 2022Review
- Dynamic Covalent Self-Assembly of Chloride- and Ion-Pair-Templated Cryptates.Angewandte Chemie (International ed. in English) · 2022Article
- Calix[6]arenes with halogen bond donor groups as selective and efficient anion transporters.Chemical communications (Cambridge, England) · 2022Article
- Ion Channels and Transporters as Therapeutic Agents: From Biomolecules to Supramolecular Medicinal Chemistry.Biomedicines · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial anion carriers (anionophores). Here, we screened 22 anionophores for biological activity using fluorescence emission from the halide-sensitive yellow fluorescent protein. Three compounds possessed anion transport activity similar to or greater than that of a bis-(
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.