Highly stereoselective nickel-catalyzed difluoroalkylation of aryl ketones to tetrasubstituted monofluoroalkenes and quaternary alkyl difluorides.

Chao Li, Yi-Xuan Cao, Ruo-Xing Jin, Kang-Jie Bian, Zi-Yang Qin, Quan Lan, Xi-Sheng Wang

Abstract read

In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Cobalt-catalyzed decarboxylative difluoroalkylation of nitrophenylacetic acid salts.Chemical science · 2023
Article
Recent Trends in Photocatalytic Enantioselective Reactions.Topics in current chemistry (Cham) · 2022
Review
Vessel effects in organic chemical reactions; a century-old, overlooked phenomenon.Chemical science · 2022
Review
On the application of 3d metals for C-H activation toward bioactive compounds: The key step for the synthesis of silver bullets.Beilstein journal of organic chemistry · 2021
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chao LiHefei National Laboratory for Physical Sciences at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis of CAS , University of Science and Technology of China , Hefei , Anhui 230026 , China . Email: xswang77@ustc.edu.cn.

Yi-Xuan CaoHefei National Laboratory for Physical Sciences at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis of CAS , University of Science and Technology of China , Hefei , Anhui 230026 , China . Email: xswang77@ustc.edu.cn.

Ruo-Xing JinHefei National Laboratory for Physical Sciences at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis of CAS , University of Science and Technology of China , Hefei , Anhui 230026 , China . Email: xswang77@ustc.edu.cn.ORCID 0000-0002-6381-148X

Kang-Jie BianHefei National Laboratory for Physical Sciences at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis of CAS , University of Science and Technology of China , Hefei , Anhui 230026 , China . Email: xswang77@ustc.edu.cn.

Zi-Yang QinHefei National Laboratory for Physical Sciences at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis of CAS , University of Science and Technology of China , Hefei , Anhui 230026 , China . Email: xswang77@ustc.edu.cn.

Quan LanHefei National Laboratory for Physical Sciences at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis of CAS , University of Science and Technology of China , Hefei , Anhui 230026 , China . Email: xswang77@ustc.edu.cn.

Xi-Sheng WangHefei National Laboratory for Physical Sciences at the Microscale , Department of Chemistry , Center for Excellence in Molecular Synthesis of CAS , University of Science and Technology of China , Hefei , Anhui 230026 , China . Email: xswang77@ustc.edu.cn.ORCID 0000-0003-2398-5669

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nickel-catalyzed difluoroalkylation of α-C-H bonds of aryl ketones to furnish highly stereo-defined tetrasubstituted monofluoroalkenes or quaternary alkyl difluorides from secondary or tertiary ketones, respectively, has been established. Mechanistic investigations indicated that these C-H fluoroalkylations proceed

Identifiers

PMID32055314

DOI10.1039/c9sc02806d

PMCPMC7003883

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