Evidence map›Paper›PMID 32055313›Full record

ArticleChemical science2019

Engineering protein polymers of ultrahigh molecular weight

Ruidi Wang, Jiayu Li, Xiumei Li, Jin Guo, Junqiu Liu, Hongbin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruidi WangState Key Laboratory of Supramolecular Structure and Materials , College of Chemistry , Jilin University , Changchun 130012 , P. R. China.
Jiayu LiDepartment of Chemistry , The University of British Columbia , Vancouver , BC V6T 1Z1 , Canada . Email: hongbin@chem.ubc.ca.
Xiumei LiState Key Laboratory of Supramolecular Structure and Materials , College of Chemistry , Jilin University , Changchun 130012 , P. R. China.
Jin GuoDepartment of Chemistry , The University of British Columbia , Vancouver , BC V6T 1Z1 , Canada . Email: hongbin@chem.ubc.ca.
Junqiu LiuState Key Laboratory of Supramolecular Structure and Materials , College of Chemistry , Jilin University , Changchun 130012 , P. R. China.ORCID 0000-0002-0533-171X
Hongbin LiDepartment of Chemistry , The University of British Columbia , Vancouver , BC V6T 1Z1 , Canada . Email: hongbin@chem.ubc.ca.ORCID 0000-0001-7813-1332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The giant muscle protein titin is the largest protein in cells and responsible for the passive elasticity of muscles. Titin, made of hundreds of individually folded globular domains, is a protein polymer with folded globular domains as its macromonomers. Due to titin's ultrahigh molecular weight, it has been challenging to engineer high molecular weight artificial protein polymers that mimic titin. Taking advantage of protein fragment reconstitution (PFR) of a small protein GB1, which can be reconstituted from its two split fragments G

Identifiers

PMID32055313
PMCPMC7003960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.