Trial reportScientific reports2020
Effect of Scalp Nerve Block with Ropivacaine on Postoperative Pain in Patients Undergoing Craniotomy: A Randomized, Double Blinded Study.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04648358 (REDUCE Trial), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REDUCE Trial: The Effects of Perineural Dexamethasone on Scalp Nerve Blocks for Relief of Postcraniotomy Pain
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Level of evidence of enhanced recovery after surgery (ERAS) strategies for elective craniotomy: An updated systematic review.Neurosurgical review · 2026Pooled it
- Prevention of Post-Operative Pain after Elective Brain Surgery: A Meta-Analysis of Randomized Controlled Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- The Scalp Nerve Block Combined with Intercostal Nerve Block Improves Recovery After Deep Brain Stimulation in Patients with Parkinson's Disease: A Prospective, Randomized Controlled Trial.Clinical interventions in aging · 2024Trial
- Ultrasound-guided scalp nerve block in anesthesia of children receiving cranial suture reconstruction.BMC anesthesiology · 2023Trial
- A pilot comparative study of intraoperative results and surgical outcomes between asleep-awake-asleep and general anesthesia modalities in temporal lobe resections.Neurosurgical review · 2026Article
- Association of Scalp Nerve Block with Perioperative Outcomes and Postoperative Complications During Subthalamic Nucleus Deep Brain Stimulation: A Single-Center Retrospective Cohort Study.Journal of pain research · 2026Article
- Regional scalp block for post-craniotomy pain management in children: a scoping review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Article
- Single versus multisite intercostal nerve block for post-thoracoscopic pain: a prospective observational study.Journal of thoracic disease · 2025Article
- Effect of ultrasound-guided scalp nerve block on hemodynamics and postoperative agitation in hypertensive cerebral hemorrhage craniotomy patients: a prospective randomized controlled study.Frontiers in neurology · 2025Article
- Scalp block versus intravenous parecoxib for post-operative cranioplasty surgery pain: A comparison of pain scores and morphine requirements.Surgical neurology international · 2025Article
- Efficacy of Dexamethasone as an Adjuvant for Scalp Nerve Blocks to Prolong Analgesia: A Prospective, Double-Blind, Randomized Controlled Study.Journal of pain research · 2025Article
- Nerve Blocks for Craniotomy.Current pain and headache reports · 2024Review
- Effects of Scalp Nerve Block on the Quality of Recovery after Minicraniotomy for Clipping of Unruptured Intracranial Aneurysms : A Randomized Controlled Trial.Journal of Korean Neurosurgical Society · 2023Article
- Successful anesthesia management with inhalation anesthesia in Rosai-Dorfman disease: a case report.The Journal of international medical research · 2023Article
- Article
- Article
- Ropivacaine instillation through subgaleal drain: A novel approach for acute post-craniotomy pain.Indian journal of anaesthesia · 2022Article
- Scalp block for postoperative pain after craniotomy: A meta-analysis of randomized control trials.Frontiers in surgery · 2022Review
- Effect of scalp nerve block with ropivacaine on postoperative pain in pediatric patients undergoing craniotomy: A randomized controlled trial.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scalp nerve block with ropivacaine has been shown to provide perioperative analgesia. However, the best concentration of ropivacaine is still unknown for optimal analgesic effects. We performed a prospective study to evaluate the effects of scalp nerve block with varied concentration of ropivacaine on postoperative pain and intraoperative hemodynamic variables in patients undergoing craniotomy under general anesthesia. Eighty-five patients were randomly assigned to receive scalp block with either 0.2% ropivacaine, 0.33% ropivacaine, 0.5% ropivacaine, or normal saline. Intraoperative hemodynamics and post-operative pain scores at 2, 4, 6, 24 hours postoperatively were recorded. We found that scalp blockage with 0.2% and 0.33% ropivacaine provided adequate postoperative pain relief up to 2 h, while administration of 0.5% ropivacaine had a longer duration of action (up to 4 hour after craniotomy). Scalp nerve block with varied concentration of ropivacaine blunted the increase of mean arterial pressure in response to noxious stimuli during incision, drilling, and sawing skull bone. 0.2% and 0.5% ropivacaine decreased heart rate response to incision and drilling. We concluded that scalp block using 0.5% ropivacaine obtain preferable postoperative analgesia compared to lower concentrations. And scalp block with ropivacaine also reduced hemodynamic fluctuations in craniotomy operations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.