ArticleScientific reports2020
Composite diagnostic criteria are problematic for linking potentially distinct populations: the case of frailty.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Systematic review of the utility of the frailty index and frailty phenotype to predict all-cause mortality in older people.Systematic reviews · 2022Pooled it
- Social Risks and Nonadherence to Recommended Cancer Screening Among US Adults.JAMA network open · 2025Article
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- Data-driven health deficit assessment improves a frailty index's prediction of current cognitive status and future conversion to dementia: results from ADNI.GeroScience · 2023Article
- Diagnostic accuracy of symptoms for an underlying disease: a simulation study.Scientific reports · 2022Article
- Frailty does not cause all frail symptoms: United States Health and Retirement Study.PloS one · 2022Article
- Why Mental Illness Diagnoses Are Wrong: A Pilot Study on the Perspectives of the Public.Frontiers in psychiatry · 2022Article
- Interpretable Trials: Is Interpretability a Reason Why Clinical Trials Fail?Frontiers in medicine · 2021Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Composite diagnostic criteria are common in frailty research. We worry distinct populations may be linked to each other due to complicated criteria. We aim to investigate whether distinct populations might be considered similar based on frailty diagnostic criteria. The Functional Domains Model for frailty diagnosis included four domains: physical, nutritive, cognitive and sensory functioning. Health and Retirement Study participants with two or more deficiencies in the domains were diagnosed frail. The survival distributions were analyzed using discrete-time survival analysis. The distributions of the demographic characteristics and survival across the groups diagnosed with frailty were significantly different (p < 0.05). A deficiency in cognitive functioning was associated with the worst survival pattern compared with a deficiency in the other domains (adjusted p < 0.05). The associations of the domains with mortality were cumulative without interactions. Cognitive functioning had the largest effect size for mortality prediction (Odds ratios, OR = 2.37), larger than that of frailty status (OR = 1.92). The frailty diagnostic criteria may take distinct populations as equal and potentially assign irrelevant interventions to individuals without corresponding conditions. We think it necessary to review the adequacy of composite diagnostic criteria in frailty diagnosis.
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