ArticleNature communications2020
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 122 citations in OpenAlex.
- A case study of evolutionary variability and determinism among type III polyketide synthases.Nature communications · 2026Article
- Research progress on flavonoid-mediated communication between plants and rhizosphere microorganisms.Archives of microbiology · 2026Review
- PlantInternational journal of molecular sciences · 2026Review
- Tuning reductase activity in monoterpene indole alkaloid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Study on biosynthesis pathway and accumulation mechanism of the dihydrochalcones inHorticulture research · 2026Article
- Molecular mechanism underlying regulation of chalcone synthase by chalcone isomerase-like protein.Nature communications · 2026Article
- Protective role of lycopene against salinity-induced oxidative stress in Medicago sativa L. seedlings.Scientific reports · 2026Article
- Protein-Protein Interactions Modulate a Key Branch Point in Monoterpene Indole Alkaloid Biosynthesis.ACS chemical biology · 2026Article
- Comprehensive review of biosynthesis, plant function, metabolism and new therapeutic bioactivities of flavonoids.ADMET & DMPK · 2026Review
- Diversity and ecological functions of anthocyanins.BMC plant biology · 2025Review
- De novo biosynthesis ofBiodesign research · 2025Article
- Functional analysis of type II chalcone isomerase (GM crops & food · 2025Article
- Identification of Chalcone Synthase Genes and Their Responses to Salt and Cold Stress inPlants (Basel, Switzerland) · 2025Article
- Protection of naringenin chalcone by a pathogenesis-related 10 protein promotes flavonoid biosynthesis in Marchantia polymorpha.The New phytologist · 2025Article
- Antitumor Activity, Mechanisms of Action and Phytochemical Profiling of Sub-Fractions Obtained fromMolecules (Basel, Switzerland) · 2025Article
- Functional phytochemicals in tomatoes: biosynthesis, gene regulation, and human health implications.Frontiers in plant science · 2025Review
- Development of phytochemical genomics: From decoding metabolome to functional genomics and biotechnology of plant metabolism.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Biochemical evaluation of molecular parts for flavonoid production using plant synthetic biology.Frontiers in plant science · 2025Review
- Evolutionary landscape of plant chalcone isomerase-fold gene families.Frontiers in plant science · 2025Article
- Evolutionary analysis of anthocyanin biosynthetic genes: insights into abiotic stress adaptation.Plant molecular biology · 2024Review
3 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Land plants produce diverse flavonoids for growth, survival, and reproduction. Chalcone synthase is the first committed enzyme of the flavonoid biosynthetic pathway and catalyzes the production of 2',4,4',6'-tetrahydroxychalcone (THC). However, it also produces other polyketides, including p-coumaroyltriacetic acid lactone (CTAL), because of the derailment of the chalcone-producing pathway. This promiscuity of CHS catalysis adversely affects the efficiency of flavonoid biosynthesis, although it is also believed to have led to the evolution of stilbene synthase and p-coumaroyltriacetic acid synthase. In this study, we establish that chalcone isomerase-like proteins (CHILs), which are encoded by genes that are ubiquitous in land plant genomes, bind to CHS to enhance THC production and decrease CTAL formation, thereby rectifying the promiscuous CHS catalysis. This CHIL function has been confirmed in diverse land plant species, and represents a conserved strategy facilitating the efficient influx of substrates from the phenylpropanoid pathway to the flavonoid pathway.
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