ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Area-Specific Synapse Structure in Branched Posterior Nucleus Axons Reveals a New Level of Complexity in Thalamocortical Networks.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 66 citations in OpenAlex.
- Review
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Presynaptic control of top-down signaling in neocortical layer 1.bioRxiv : the preprint server for biology · 2026Article
- Biophysical modeling of thalamocortical circuit dynamics: species-specific insights into neural synchrony, sleep spindles, and circuit mechanisms.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Pathway-Specific Ultrastructure of Thalamocortical Synapses in Mouse Somatosensory Area S2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Differences in motor learning-related structural plasticity of layer 2/3 parvalbumin-positive interneurons of the young and aged motor cortex.GeroScience · 2025Article
- The Cortical Structural Model Extends to Thalamocortical Connections.The European journal of neuroscience · 2025Article
- Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.eLife · 2025Article
- Projection Motifs and Wiring Logic of Medial Pulvinar Thalamocortical Axons in the Marmoset Monkey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Beyond Barrels: Diverse Thalamocortical Projection Motifs in the Mouse Ventral Posterior Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spike transmission failures in axons from cortical neuronsiScience · 2024Article
- Tracing nerve fibers with volume electron microscopy to quantitatively analyze brain connectivity.Communications biology · 2024Article
- Spike transmission failures in axons from mouse cortical pyramidal neurons in vivo.bioRxiv : the preprint server for biology · 2024Article
- Cellular and laminar architecture: A short history and commentary.The Journal of comparative neurology · 2023Article
- High-Resolution Tractography Protocol to Investigate the Pathways between Human Mediodorsal Thalamic Nucleus and Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Micropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs.Frontiers in neuroanatomy · 2023Article
- Cerebellar and basal ganglia inputs define three main nuclei in the mouse ventral motor thalamus.Frontiers in neuroanatomy · 2023Article
- Translating single-neuron axonal reconstructions into meso-scale connectivity statistics in the mouse somatosensory thalamus.Frontiers in neuroinformatics · 2023Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thalamocortical posterior nucleus (Po) axons innervating the vibrissal somatosensory (S1) and motor (MC) cortices are key links in the brain neuronal network that allows rodents to explore the environment whisking with their motile snout vibrissae. Here, using fine-scale high-end 3D electron microscopy, we demonstrate in adult male C57BL/6 wild-type mice marked differences between MC versus S1 Po synapses in (1) bouton and active zone size, (2) neurotransmitter vesicle pool size, (3) distribution of mitochondria around synapses, and (4) proportion of synapses established on dendritic spines and dendritic shafts. These differences are as large, or even more pronounced, than those between Po and ventro-posterior thalamic nucleus synapses in S1. Moreover, using single-axon transfection labeling, we demonstrate that the above differences actually occur on the MC versus the S1 branches of individual Po cell axons that innervate both areas. Along with recently-discovered divergences in efficacy and plasticity, the synaptic structure differences reported here thus reveal a new subcellular level of complexity. This is a finding that upends current models of thalamocortical circuitry, and that might as well illuminate the functional logic of other branched projection axon systems.
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