ArticleESMO open2020
Impact of prior cancer history on the overall survival of younger patients with lung cancer.
Article in ESMO open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Indeterminate pulmonary nodules and prior malignancy: survival and recurrence after surgery in newly diagnosed stage I non-small cell lung cancer.Journal of thoracic disease · 2024Article
- Medical history of thyroid cancer does not impair prognosis in non-metastatic breast cancer patients: an analysis study based on SEER database and external cohort.Frontiers in oncology · 2024Article
- Prognostic impact of the presence or absence of prior cancer in patients with cancer using cure models: A population-based study.Cancer science · 2023Article
- Racial and Ethnic Disparities in Survival Among People With Second Primary Cancer in the US.JAMA network open · 2023Article
- Survival in non-small cell lung cancer patients with versus without prior cancer.Scientific reports · 2023Article
- Prior cancer history predicts the worse survival of patients with nasopharyngeal carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Effect of prior thyroid cancer on survival of primary liver cancer: a study based on the SEER database.Scientific reports · 2022Article
- Get insight into the cause of death distribution and epidemiology of penile squamous cell carcinoma: A population-based study.Cancer medicine · 2022Article
- Risk and prognosis of secondary bladder cancer after post-operative radiotherapy for gynecological cancer.Bosnian journal of basic medical sciences · 2022Article
- Effect of prior malignancy on the prognosis of gastric cancer and somatic mutation.World journal of clinical cases · 2022Article
- Increased risk of secondary bladder cancer after radiation therapy for endometrial cancer.Scientific reports · 2022Article
- Adjuvant chemotherapy may improve long-term outcomes in stage IB non-small cell lung cancer patients with previous malignancies: A propensity score-matched analysis.Frontiers in oncology · 2022Article
- Survival outcomes in prostate cancer patients with a prior cancer.Translational andrology and urology · 2021Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with a history of prior cancer are frequently excluded from cancer trials. Previous studies indicated that prior cancer does not adversely impact clinical outcomes for patients with lung cancer older than 65 years. However, it remains unknown whether these results are applicable to patients with lung cancer aged younger than 65 years old. The study aimed to investigate the impact of prior cancer history on younger patients with lung cancer.
methodsWe identified younger patients with lung cancer (<65 years) diagnosed between 2004 and 2009 in the Surveillance, Epidemiology, and End Results database. Propensity score matching was performed to balance differences in baseline characteristics between groups. Kaplan-Meier method and the Cox proportional hazards model were used to evaluate the impact of prior cancer on overall survival (OS).
resultsAmong 103 370 eligible patients with lung cancer, 15.18% had a history of prior cancer. Lung and bronchus (25.83%), breast (14.13%), prostate (8.85%) and cervix uteri (4.74%) were the most common prior cancer types. Of prior cancers, 61.56% are localised and regional stages. More than 67.98% of prior cancers were diagnosed within 5 years of the index lung cancer diagnosis. The median times of diagnosis for prior cancers were 38 months. Patients with prior cancer had the same/non-inferior OS as that of patients without a prior cancer diagnosis (propensity score-adjusted HR=1.01, 95% CI=0.99 to 1.04, p=0.324). Subgroup analyses stratified by timing of prior cancer displayed almost the same tendency (p>0.05). Interestingly, early-stage patients with a history of prior cancer had adverse survival curves (p<0.05). Advanced-stage patients with prior cancer had non-inferior survival (p>0.05).
conclusionsA prior cancer diagnosis has a heterogeneous effect on the survival of patients with lung cancer aged <65 years across different stages, but further prospective studies are still warranted.
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