ArticleAJNR. American journal of neuroradiology2020
Is Low-Grade Intraventricular Hemorrhage in Very Preterm Infants an Innocent Condition? Structural and Functional Evaluation of the Brain Reveals Regional Neurodevelopmental Abnormalities.
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Structural and functional connectivity of the brain in premature infants with non-hemorrhagic punctate white matter lesions: a graph analysis.Pediatric radiology · 2026Article
- Promising Preventive Strategies for Intraventricular Hemorrhage in Preterm Neonates: A Critical Review.Journal of clinical medicine · 2025Review
- Functional connectivity of the pediatric brain.Neuroradiology · 2024Review
- Associations between diffusion kurtosis imaging metrics and neurodevelopmental outcomes in neonates with low-grade germinal matrix and intraventricular hemorrhage.Scientific reports · 2024Article
- Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center.BMC pediatrics · 2024Article
- Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage.Scientific reports · 2024Article
- Hippocampal volumes and cognitive performance in children born extremely preterm with and without low-grade intraventricular haemorrhage.Brain structure & function · 2023Article
- The Long-Term Outcome and Rehabilitative Approach of Intraventricular Hemorrhage at Preterm Birth.Journal of Korean Neurosurgical Society · 2023Article
- Extreme prematurity and perinatal risk factors related to extremely preterm birth are associated with complex patterns of regional brain volume alterations at 10 years of age: a voxel-based morphometry study.Frontiers in neurology · 2023Article
- Long-term neurodevelopmental outcome in preterm infants with intraventricular haemorrhage.Journal of paediatrics and child health · 2022Article
- Structural and functional brain connectivity in moderate-late preterm infants with low-grade intraventricular hemorrhage.Neuroradiology · 2022Article
- The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study.Frontiers in neurology · 2021Article
- Decreased Incidence of Intraventricular Hemorrhage in Extremely Low Birth Weight Infants Using Customized Circulatory Management to Evaluate the Hemodynamic Change of Patent Ductus Arteriosus.Frontiers in pediatrics · 2021Article
- Regional impairment of cortical and deep gray matter perfusion in preterm neonates with low-grade germinal matrix-intraventricular hemorrhage: an ASL study.Neuroradiology · 2020Observational
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is increasing evidence of abnormal neurodevelopmental outcomes in very preterm infants with low-grade intraventricular hemorrhage grades I and II. Our purpose was to evaluate the effects of low-grade intraventricular hemorrhage on gray and white matter integrity. MATERIALS AND
methodsMR imaging at around term-equivalent age was performed in 16 very preterm infants (mean gestational age, 28.8 ± 5.3 weeks) with mild intraventricular hemorrhage on brain sonography and 13 control subjects (mean gestational age, 29.6 ± 4.1 weeks) without intraventricular hemorrhage. Structural and functional evaluation of the cortex was performed using regional measurements of surface area, thickness and volume, and resting-state fMRI, respectively, and of WM microstructural integrity, applying Tract-Based Spatial Statistics to diffusion tensor imaging data.
resultsCompared with the control infants, the infants with low-grade intraventricular hemorrhage had decreases in the following: 1) GM surface area in Brodmann areas 19 left and 9 and 45 right, and GM volume in Brodmann areas 9 and 10 right; 2) fractional anisotropy bilaterally in major WM tracts; and 3) brain activity in the left lower lateral and in the right higher medial somatosensory cortex.
conclusionsVery premature infants with low-grade intraventricular hemorrhage at around term-equivalent age may present with regional abnormalities, appearing on imaging studies as cortical underdevelopment, functional impairment, and microstructural immaturity of major WM tracts.
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