ArticleIEEE transactions on bio-medical engineering2020
In Vivo Visualization of Eye Vasculature Using Super-Resolution Ultrasound Microvessel Imaging.
Article in IEEE transactions on bio-medical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- A General-Purpose Framework for Microvascular Reconstruction and Quantitative Analysis in Ultrasound Localization Microscopy.BME frontiers · 2026Article
- Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors.Journal of biomechanical engineering · 2025Article
- Enhanced ultrasound particle image velocimetry (E-uPIV) enables fast flow mapping of microvasculature.Communications engineering · 2025Article
- Application of Ultrasound Localization Microscopy in Evaluating the Type 2 Diabetes Progression.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia.bioRxiv : the preprint server for biology · 2024Article
- Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys.bioRxiv : the preprint server for biology · 2024Article
- The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure.Investigative ophthalmology & visual science · 2024Article
- Article
- Fast 3D Super-Resolution Ultrasound With Adaptive Weight-Based Beamforming.IEEE transactions on bio-medical engineering · 2023Article
- Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy.Bioengineering (Basel, Switzerland) · 2023Article
- Super-Resolution Ultrasound Through Sparsity-Based Deconvolution and Multi-Feature Tracking.IEEE transactions on medical imaging · 2022Article
- [Super-resolution ultrasound imaging : Methods and applications].Radiologie (Heidelberg, Germany) · 2022Review
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Super-Resolution Ultrasound Localization Microscopy for Visualization of the Ocular Blood Flow.IEEE transactions on bio-medical engineering · 2022Article
- Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy.Experimental eye research · 2022Article
- Magnetic Nano-Platform Enhanced iPSC-Derived Trabecular Meshwork Delivery and Tracking Efficiency.International journal of nanomedicine · 2022Article
- Automated Detection and Diagnosis of Diabetic Retinopathy: A Comprehensive Survey.Journal of imaging · 2021Review
- Retrobulbar blood flow in rat eyes during acute elevation of intraocular pressure.Experimental eye research · 2021Article
- Current Development and Applications of Super-Resolution Ultrasound Imaging.Sensors (Basel, Switzerland) · 2021Review
- Super-Resolution Microscopy: Shedding New Light onFrontiers in chemistry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe choroidal vessels, which supply oxygen and nutrient to the retina, may play a pivotal role in eye disease pathogenesis such as diabetic retinopathy and glaucoma. In addition, the retrobulbar circulation that feeds the choroid shows an important pathophysiologic role in myopia and degenerative myopia. Owing to the light-absorbing retinal pigment epithelium (RPE) and optically opaque sclera, choroidal and retrobulbar vasculature were difficult to be observed using clinically accepted optical coherence tomography angiography (OCT-A) technique. Here, we have developed super-resolution ultrasound microvessel imaging technique to visualize the deep ocular vasculature.
methodsAn 18-MHz linear array transducer with compounding plane wave imaging technique and contrast agent - microbubble was implemented in this study. The centroid intensity of each microbubble was detected using image deconvolution algorithm with spatially variant point spread function, and then accumulated in successive frames in order to reconstruct microvasculature. The image deconvolution technique was first evaluated in a simulation study and experimental flow phantoms. The performance was then validated on normal rabbit eyes in vivo.
resultsThe image deconvolution based super-resolution ultrasound microvessel imaging technique shows good performance on either simulation study or flow phantoms. In vivo rabbit eye study indicated that the micron-level choroidal and retrobulbar vessels around the optic nerve head were successfully reconstructed in multiple 2D views and 3D volume imaging.
conclusionsOur results demonstrate the capability of using super-resolution ultrasound microvessel imaging technique to image the microvasculature of the posterior pole of the eye. This efficient approach can potentially lead to a routinely performed diagnostic procedure in the field of ophthalmology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.