ArticleBMC psychiatry2020
The relationship between dietary patterns and depression mediated by serum levels of Folate and vitamin B12.
Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- The association of ultra-processed food intake on age-related muscle conditions: a systematic review and dose-response meta-analysis with meta-regression.Journal of health, population, and nutrition · 2025Pooled it
- Association between junk food consumption and mental health problems in adults: a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression.Journal of translational medicine · 2025Trial
- Trial
- The relationship between homocysteine and post-stroke depression in patients with spontaneous intracerebral hemorrhage.BMC neurology · 2026Article
- Dietary and other lifestyle correlates of serum folate levels among female students at An-Najah National University in Palestine: a cross-sectional study.BMC nutrition · 2026Article
- Vitamin B12 and Affective Disorders: A Focus on the Gut-Brain Axis.Alpha psychiatry · 2025Review
- Therapeutic Horizons: Gut Microbiome, Neuroinflammation, and Epigenetics in Neuropsychiatric Disorders.Cells · 2025Review
- Associations between takeaway food consumption, physical activity levels, and their joint effect with comorbid depression and anxiety symptoms among Chinese university students.BMC public health · 2025Article
- Association between homocysteine levels and cognition in late-life depression.Frontiers in psychiatry · 2025Article
- Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database.Frontiers in nutrition · 2025Article
- Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration.International journal of molecular sciences · 2024Review
- Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study.Nutrients · 2024Article
- Vitamin B12 and homocysteine in patients with major depressive disorder.Journal of family medicine and primary care · 2024Article
- Systematic Review and Meta-analysis of the Association Between Malnutrition and Risk of Depression in the Elderly.Alpha psychiatry · 2024Review
- Major depressive disorder: hypothesis, mechanism, prevention and treatment.Signal transduction and targeted therapy · 2024Review
- Association between suicide attempts and anemia in late-life depression inpatients.BMC geriatrics · 2024Article
- Psychosocial profiles influencing healthy dietary behaviors among adolescents in Shandong Province, China: a cross-sectional study.Frontiers in nutrition · 2024Article
- Pathogenesis and therapeutic strategies for cancer-related depression.American journal of cancer research · 2024Review
- Using genetic variations to reveal the complex relationships between vegetarianism and well-being, depressive symptoms and neuroticism.Frontiers in nutrition · 2024Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder is among main worldwide causes of disability. The low medication compliance rates in depressed patients as well as the high recurrence rate of the disease can bring up the nutrition-related factors as a potential preventive or treatment agent for depression. The aim of this study was to investigate the association between dietary patterns and depression via the intermediary role of the serum folate and vitamin B12, total homocysteine, tryptophan, and tryptophan/competing amino acids ratio.
methodsThis was an individually matched case-control study in which 110 patients with depression and 220 healthy individuals, who completed a semi-quantitative food frequency questionnaire were recruited. We selected the depressed patients from three districts in Tehran through non-probable convenience sampling from which healthy individuals were selected, as well. The samples selection and data collection were performed during October 2012 to June 2013. In addition, to measure the serum biomarkers 43 patients with depression and 43 healthy people were randomly selected from the study population. To diagnose depression the criteria of Diagnostic and Statistical Manual of Mental Disorders, fourth edition, were utilized.
resultsThe findings suggest that the healthy dietary pattern was significantly associated with a reduced odds of depression (OR: 0.75; 95% CI: 0.61-0.93) whereas the unhealthy dietary pattern increased it (OR: 1.382, CI: 1.116-1.71). The mediation analysis showed that the healthy dietary pattern was associated with a reduced risk of depression via increased serum levels of the folate and vitamin B12; however, the unhealthy dietary pattern was associated with increased risk of depression via decreased serum levels of folate and vitamin B12, based on tree adjusted logistic regression models.
conclusionDietary patterns may be associated with depression by changing the serum levels of folate and vitamin B12. Further studies are required to confirm the mechanism.
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