Evidence map›Paper›PMID 32054514›Full record

ArticleStem cell research & therapy2020

Multipotency of mouse trophoblast stem cells.

Minmin Hou, Junwen Han, Gu Li, Min-Young Kwon, Jiani Jiang, Sirisha Emani, Elizabeth S Taglauer, Jin-Ah Park, Eun-Bee Choi, Munender Vodnala and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Current Status of Synthetic Mammalian Embryo Models.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Minmin HouDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Junwen HanDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Gu LiDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Min-Young KwonDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Jiani JiangDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Sirisha EmaniDepartment of Cardiovascular Surgery, Children's Hospital, Boston, MA, USA.
Elizabeth S TaglauerDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Jin-Ah ParkDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
Eun-Bee ChoiDepartment of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Munender VodnalaDepartment of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Yick W FongDepartment of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sitaram M EmaniDepartment of Cardiovascular Surgery, Children's Hospital, Boston, MA, USA.
Ivan O RosasDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Mark A PerrellaDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Xiaoli LiuDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. xlliu@rics.bwh.harvard.edu.ORCID 0000-0003-2904-4413
Brigham and Women's Hospital · USBoston Children's Hospital · US

Funding

Physics of bronchial epithelial unjammingR01HL148152 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, PARK, JIN-AH · 2019 to 2022
$2.2M
Stem cell-specific transcriptional control by dyskerin ribonucleoprotein complexR01HL125527 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FONG, YICK WAH · 2016 to 2019
$1.8M
Cardiomyocyte Differentiation Regulates Cardiac FunctionR01HL102897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A · 2011 to 2014
$1.7M
NHLBI NIH HHS R01 HL102897NHLBI NIH HHS R01 HL125527NHLBI NIH HHS R01 HL148152
6 · The paper itself

Abstract

backgroundIn a number of disease processes, the body is unable to repair injured tissue, promoting the need to develop strategies for tissue repair and regeneration, including the use of cellular therapeutics. Trophoblast stem cells (TSCs) are considered putative stem cells as they differentiate into other subtypes of trophoblast cells. To identify cells for future therapeutic strategies, we investigated whether TSCs have properties of stem/progenitor cells including self-renewal and the capacity to differentiate into parenchymal cells of fetal organs, in vitro and in vivo.

methodsTSCs were isolated using anti-CD117 micro-beads, from embryonic day 18.5 placentas. In vitro, CD117

resultsWe first identified CD117

conclusionsOur findings demonstrate that CD117

Indexed as

AnimalsCell DifferentiationImmunohistochemistryMiceStem CellsTrophoblastsIn uteroMultipotencyStem cellsTrophoblast cells

Identifiers

PMID32054514
PMCPMC7020558
OpenAlexW3009791026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.