Evidence map›Paper›PMID 32054486›Full record

Trial reportJournal of the International Society of Sports Nutrition2020

The acute effects of thermogenic fitness drink formulas containing 140 mg and 100 mg of caffeine on energy expenditure and fat metabolism at rest and during exercise.

Nicolas W Clark, Adam J Wells, Nicholas A Coker, Erica R Goldstein, Chad H Herring, Tristan M Starling-Smith, Alyssa N Varanoske, Valeria L G Panissa, Jeffrey R Stout, David H Fukuda

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05061797 (A Double-Blind, Randomized, Crossover Study to Examine the Thermogenic Effect of an Energy Drink in Healthy Adults), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05061797 nacompletednot on this mapstarted 2021, after this paper: background citation

A Double-Blind, Randomized, Crossover Study to Examine the Thermogenic Effect of an Energy Drink in Healthy Adults

TypeinterventionalSponsorRowdy EnergyRan2021 to 2021Enrolled30ConditionsMetabolismArmsThermogenic Energy Drink - Active Study Product Formula, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Validity and reliability ofSports medicine and health science · 2026
    Article
  5. Review
  6. International society of sports nutrition position stand: energy drinks and energy shots.Journal of the International Society of Sports Nutrition · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Nicolas W ClarkSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
Adam J WellsSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
Nicholas A CokerSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
Erica R GoldsteinSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
Chad H HerringSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
Tristan M Starling-SmithSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
Alyssa N VaranoskeSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
Valeria L G PanissaDepartment of Sport, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Jeffrey R StoutSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA.
David H FukudaSchool of Kinesiology and Physical Therapy, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. david.fukuda@ucf.edu.ORCID http://orcid.org/0000-0002-4299-7764
University of Central Florida · USUniversidade de São Paulo · BR

Funding

Celsius Holdings Inc. 1063638
6 · The paper itself

Abstract

backgroundThermogenic fitness drink formulas (TFD) have been shown to increase energy expenditure and markers of lipid metabolism. The purpose of the current study was to compare TFD formulas containing different caffeine concentrations versus a placebo drink on energy expenditure and lipid metabolism at rest and during exercise.

methodsThirty-two recreationally active participants (22.9 ± 0.7 y, 167.1 ± 1.4 cm, 68.8 ± 2.0 kg, 24.0 ± 1.2% fat) who were regular caffeine consumers, participated in this randomized, double-blind, crossover design study. Participants reported to the laboratory on three occasions, each of which required consumption of either a TFD containing 140 mg or 100 mg of caffeine or a placebo. Baseline measurements of resting energy expenditure (REE) and resting fat oxidation (RFO) were assessed using indirect calorimetry as well as measurements of serum glycerol concentration. Measurements were repeated at 30, 60, 90 min post-ingestion. Following resting measures, participants completed a graded exercise test to determine maximal oxygen uptake (V̇O

resultsA significant interaction was shown for REE (p < 0.01) and RFO (p < 0.01). Area under the curve analysis showed an increased REE for the 140 mg compared to the 100 mg formula (p = 0.02) and placebo (p < 0.01) and an increased REE for the 100 mg formula compared to placebo (p = 0.02). RFO significantly decreased for caffeinated formulas at 30 min post ingestion compared to placebo and baseline (p < 0.01) and significantly increased for the 140 mg formula at 60 min post-ingestion (p = 0.03). A main effect was shown for serum glycerol concentrations over time (p < 0.01). No significant differences were shown for V̇O

conclusionsOur results suggest that TFD formulas containing 100 and 140 mg of caffeine are effective in increasing REE and that a 40 mg of caffeine difference between the tested formulas may impact REE and RFO in healthy individuals within 60 min of ingestion.

Indexed as

Energy MetabolismExerciseLipid MetabolismAdolescentAdultBeveragesCaffeineCalorimetry, IndirectCross-Over StudiesDouble-Blind MethodExercise TestFemaleGlycerolHumansMalePerformance-Enhancing SubstancesCaffeineGlycerolPerformance-Enhancing SubstancesCaffeineCaloric expenditureEnergy drinksExerciseFat oxidation

Identifiers

PMID32054486
PMCPMC7020555
OpenAlexW3009743169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.