Evidence map›Paper›PMID 32053991›Full record

ArticleInternational journal of molecular sciences2020

Establishment and Characterization of a Brca1

Lilla Hámori, Gyöngyi Kudlik, Kornélia Szebényi, Nóra Kucsma, Bálint Szeder, Ádám Póti, Ferenc Uher, György Várady, Dávid Szüts, József Tóvári and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  7. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Lilla HámoriInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Gyöngyi KudlikInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Kornélia SzebényiInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Nóra KucsmaInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Bálint SzederInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Ádám PótiInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Ferenc UherCentral Hospital of Southern Pest-National Institute of Hematology and Infectious Diseases, 1097 Budapest, Hungary.
György VáradyInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Dávid SzütsInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
József TóváriDepartment of Experimental Pharmacology, National Institute of Oncology, 1122, Budapest, Hungary.
András FürediInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Gergely SzakácsInstitute of Enzymology, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
Institute of Molecular Life Sciences · HUNational Center for Epidemiology · HUNational Institute of Oncology · HU

Funding

Magyar Tudományos Akadémia MomentumNational Research, Development and Innovation Fund of Hungary FIEK_16-1-2016-0005
6 · The paper itself

Abstract

Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. By the age of 80, the estimated risk for breast cancer for women with germline BRCA1 or BRCA2 mutations is around 80%. Genetically engineered BRCA1-deficient mouse models offer a unique opportunity to study the pathogenesis and therapy of triple negative breast cancer. Here we present a newly established Brca1

Indexed as

AnimalsBRCA1 ProteinCell Line, TumorCell ProliferationFemaleGene DeletionGenomic InstabilityMammary Neoplasms, AnimalMiceTriple Negative Breast NeoplasmsTumor Suppressor Protein p53BRCA1 ProteinTumor Suppressor Protein p53BRCA1breast cancercancer cell linegenetically engineered mouse model

Identifiers

PMID32053991
PMCPMC7072850
OpenAlexW3006464607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.