Evidence map›Paper›PMID 32053970›Full record

ReviewInternational journal of molecular sciences2020

Bone Control of Muscle Function.

Giulia Battafarano, Michela Rossi, Francesco Marampon, Salvatore Minisola, Andrea Del Fattore

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  16. Molecular communication from bone to skeletal muscle: an overview.Frontiers in cell and developmental biology · 2025
    Review
  17. Review
  18. Connecting the dots: sex, depression, and musculoskeletal health.The Journal of clinical investigation · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Giulia BattafaranoBone Physiopathology Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children's Hospital, 00165 Rome, Italy.
Michela RossiBone Physiopathology Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children's Hospital, 00165 Rome, Italy.
Francesco MaramponDepartment of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, 00151 Rome, Italy.
Salvatore MinisolaDepartment of Clinical, Internal, Anesthetic and Cardiovascular Sciences, "Sapienza" University of Rome, 00151 Rome, Italy.
Andrea Del FattoreBone Physiopathology Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children's Hospital, 00165 Rome, Italy.
Bambino Gesù Children's Hospital · ITPoliclinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone and muscle represent a single functional system and are tightly connected to each other. Indeed, diseases characterized by alterations of muscle physiology have effects on bone remodeling and structure and vice versa. Muscle influence on bone has been deeply studied, and recent studies identified irisin as new molecule involved in this crosstalk. Muscle regulation by bone needs to be extensively investigated since in the last few years osteocalcin was recognized as a key molecule in the bone-muscle interaction. Osteocalcin can exist in two forms with different degrees of carboxylation. The undercarboxylated form of osteocalcin is a hormone released by the bone matrix during the osteoclast bone resorption and can bind its G-protein coupled receptor GPRC6A expressed in the muscle, thus regulating its function. Recently, this hormone was described as an antiaging molecule for its ability to regulate bone, muscle and cognitive functions. Indeed, the features of this bone-related hormone were used to test a new therapeutic approach for sarcopenia, since injection of osteocalcin in older mice induces the acquirement of physical abilities of younger animals. Even if this approach should be tested in humans, osteocalcin represents the most surprising molecule in endocrine regulation by the skeleton.

Indexed as

ExerciseMusculoskeletal Physiological PhenomenaAnimalsBone and BonesBone ResorptionHumansMuscle, SkeletalOsteocalcinOsteoclastsReceptors, G-Protein-CoupledGPRC6A protein, humanOsteocalcinReceptors, G-Protein-Coupledbonemuscleosteocalcin

Identifiers

PMID32053970
PMCPMC7072735
OpenAlexW3006452735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.