ArticleInternational journal of molecular sciences2020
Assessment of the Phenolic Profiles, Hypoglycemic Activity, and Molecular Mechanism of Different Highland Barley (
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 83 citations in OpenAlex.
- Trial
- The influence mechanism of continuous hot-air drying on the nutritional, microstructure andFood chemistry: X · 2026Article
- Glycogen metabolic dysfunction in T2DM with MASLD: linking α-hydroxybutyrate to GYS2 downregulation.Frontiers in nutrition · 2026Article
- Roasting Improves the Bioaccessibility and Bioactivity of Polyphenols from Highland Barley with a Protective Effect in Oxidatively Damaged HepG2 Cells.Foods (Basel, Switzerland) · 2025Article
- Selenium-EnrichedFood science & nutrition · 2025Article
- Review
- In-Vitro Cytotoxic, Hypoglycaemic, and Inhibitory α-Amylase and α-Glucosidase Potential of Flour of Improved Hull-Less and Hulled Barley Varieties.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Article
- Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus.Animal models and experimental medicine · 2024Review
- Comparative Analysis of Hulless Barley Transcriptomes to Regulatory Effects of Phosphorous Deficiency.Life (Basel, Switzerland) · 2024Article
- Chemical Basis for Determining the Allelopathic Potential of Invasive Plant Wall Barley (Molecules (Basel, Switzerland) · 2024Article
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- Chemical characterization, antioxidant and antidiabetic activities of a novel polyherbal formulation comprising ofHeliyon · 2023Article
- Structural and physicochemical properties of the different ultrasound frequency modified Qingke protein.Ultrasonics sonochemistry · 2023Article
- Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran.Molecules (Basel, Switzerland) · 2023Article
- Article
- Common Ayurvedic, Chinese traditional and Unani antidiabetic formulations- a review.Frontiers in pharmacology · 2022Review
- Genome-Wide Identification of Genes Related to Biosynthesis of Phenolic Acid Derivatives inFrontiers in plant science · 2022Article
- Food and Grain Consumption Per Capita in the Qinghai-Tibet Plateau and Implications for Conservation.Nutrients · 2021Article
- Highland Barley and Its By-Products Enriched with Phenolic Compounds for Inhibition of Pyrraline Formation by Scavenging α-Dicarbonyl Compounds.Foods (Basel, Switzerland) · 2021Article
- Diversity of Culturable Bacteria Isolated from Highland Barley Cultivation Soil in Qamdo, Tibet Autonomous Region.Polish journal of microbiology · 2021Article
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4 authors at 2 institutions in 2 countries.
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Abstract
The phenolic profiles, hypoglycemic activity, and molecular mechanism of the effect on type 2 diabetes mellitus (T2DM) of four highland barley varieties were investigated in the present study. The fundamental phenolics in highland barley were ferulic acid, naringin, and catechin, which mainly existed in bound form. These varieties showed favorable hypoglycemic activity via inhibition of α-glucosidase and α-amylase activities, enhancement of glucose consumption, glycogen accumulation and glycogen synthase 2 (GYS2) activity, and down-regulation of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) activities. Specifically, ZQ320 variety exhibited the strongest hypoglycemic activity compared to the other varieties. Highland barley phenolics could inhibit gluconeogenesis and motivate glycogen synthesis via down-regulating the gene expression of G6Pase, PEPCK, and glycogen synthase kinase 3β (GSK3β), while activating the expression of insulin receptor substrate-1 (IRS-1), phosphatidylinositol 3 kinase (PI3K), serine/threonine kinase (Akt), GYS2, and glucose transporter type 4 (GLUT4). Therefore, phenolics from highland barley could be served as suitable candidates for therapeutic agent in T2DM to improve human health.
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