ArticlePediatric research2020
Microbiome of the first stool after birth and infantile colic.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06299358 (The Effect of Foot Massage and Maternal Heart Sound on Colic and Comfort Levels in Infants With Infantile Colic), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Foot Massage and Maternal Heart Sound on Colic and Comfort Levels in Infants With Infantile Colic
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study.Pediatric research · 2024Pooled it
- Faecal Microbiota in Infants and Young Children with Functional Gastrointestinal Disorders: A Systematic Review.Nutrients · 2022Pooled it
- Infant behavioral state and stool microbiome in infants receiving Lactocaseibacillus rhamnosus GG in formula: randomized controlled trial.BMC pediatrics · 2022Trial
- Why do babies cry? Exploring the role of the gut microbiota in infantile colic, constipation, and cramps in the KOALA birth cohort study.Gut microbes · 2025Article
- Labor Induction with Synthetic Oxytocin and Infantile Colic: A Case-Control Study.Medicina (Kaunas, Lithuania) · 2025Article
- Gut Microbiota Profile and Functional Gastrointestinal Disorders in Infants: A Longitudinal Study.Nutrients · 2025Article
- Is there a role for nutritional advice during breastfeeding for infant colic relief? A mixed-method study.Heliyon · 2025Article
- Temporal Investigation of the Maternal Origins of Fetal Gut Microbiota.Microorganisms · 2024Article
- Preventing and Treating Colic: An Update.Advances in experimental medicine and biology · 2024Review
- Compositional and functional variability of the gut microbiome in children with infantile colic.Scientific reports · 2023Observational
- Unraveling the complexity of Disorders of the Gut-Brain Interaction: the gut microbiota connection in children.Frontiers in pediatrics · 2023Review
- Review
- Infantile Colic and the Subsequent Development of the Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2022Article
- Microbiota of the first-pass meconium and subsequent atopic and allergic disorders in children.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Article
- Clinical efficacy of magnetotherapy combined with pediatric massage on infantile colic.American journal of translational research · 2022Article
- Presence of distinctive microbiome in the first-pass meconium of newborn infants.Scientific reports · 2021Article
- Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome.Scientific reports · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have shown a diverse microbiome in the first stool after birth. The clinical significance of the microbiome of the first stool is not known. Infantile colic has earlier been associated with the composition of the intestinal microbiome.
methodsWe set out to test whether the microbiome of the first stool is associated with subsequent infantile colic in a prospective, population-based cohort study of 212 consecutive newborn infants. We used next-generation sequencing of the bacterial 16S rRNA gene.
resultsThe newborns who later developed infantile colic (n = 19) had a lower relative abundance of the genus Lactobacillus and the phylum Firmicutes in the first stool than those who remained healthy (n = 139). By using all microbiome data, random forest algorithm classified newborn with subsequent colic and those who remained healthy with area under the curve of 0.66 (SD 0.03) as compared to that of shuffled samples (P value <0.001).
conclusionsIn this prospective, population-based study, the microbiome of the first-pass meconium was associated with subsequent infantile colic. Our results suggest that the pathogenesis of infantile colic is closely related to the intestinal microbiome at birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.