ArticlePhysics in medicine and biology2020
Infrared navigation system for light dosimetry during pleural photodynamic therapy.
Article in Physics in medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Anatomy-resolved digital twin framework for personalized light dosimetry in lung therapies.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Monte Carlo analysis of light fluence rate distribution in pleural photodynamic therapy: a study of geometric and optical property effects on treatment delivery.Journal of biomedical optics · 2026Article
- Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma.Pharmaceuticals (Basel, Switzerland) · 2025Article
- AAPM Task Group Report 274: Fluence rate dosimetry for photodynamic therapy (PDT).Medical physics · 2025Review
- A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy.Antioxidants (Basel, Switzerland) · 2024Article
- First in human measurements of abscess cavity optical properties and methylene blue uptake prior to photodynamic therapy byJournal of biomedical optics · 2024Article
- Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.Journal of biomedical optics · 2024Article
- Evaluation of Detector Position and Light Fluence Distribution Using an Infrared Navigation System during Pleural Photodynamic TherapyPhotochemistry and photobiology · 2023Article
- Three-dimensional image-guided topical photodynamic therapy system with light dosimetry dynamic planning and monitoring.Biomedical optics express · 2023Article
- Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study.Journal of biomedical optics · 2022Article
- Photodynamic therapy in a pleural cavity using monte carlo simulations with 2D/3D Graphical Visualization.Global journal of cancer therapy · 2022Article
- Irradiance uniformity optimization for a photodynamic therapy treatment device with 3D scanner.Journal of biomedical optics · 2021Article
- Perspectives on interstitial photodynamic therapy for malignant tumors.Journal of biomedical optics · 2021Article
- In vivo Spectroscopic Evaluation of the Intraperitoneal Cavity in Canines.Photochemistry and photobiology · 2020Article
- A Monte Carlo simulation for Moving Light Source in Intracavity PDT.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- PDT Light Fluence Phantom Modeling of the Human Pleural Cavity: A Proof-of-Concept Pre-Clinical Study.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- Real-time PDT Dose Dosimetry for Pleural Photodynamic Therapy.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates.Photochemistry and photobiologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Pleural photodynamic therapy (PDT) is performed intraoperatively for the treatment of microscopic disease in patients with malignant pleural mesothelioma. Accurate delivery of light dose is critical to PDT efficiency. As a standard of care, light fluence is delivered to the prescribed fluence using eight isotropic detectors in pre-determined discrete locations inside the pleural cavity that is filled with a dilute Intralipid solution. An optical infrared (IR) navigation system was used to monitor reflective passive markers on a modified and improved treatment delivery wand to track the position of the light source within the treatment cavity during light delivery. This information was used to calculate the light dose, incorporating a constant scattered light dose and using a dual correction method. Calculation methods were extensively compared for eight detector locations and seven patient case studies. The light fluence uniformity was also quantified by representing the unraveled three-dimensional geometry on a two-dimensional plane. Calculated light fluence at the end of treatment delivery was compared to measured values from isotropic detectors. Using a constant scattered dose for all detector locations along with a dual correction method, the difference between calculated and measured values for each detector was within 15%. Primary light dose alone does not fully account for the light delivered inside the cavity. This is useful in determining the light dose delivered to areas of the pleural cavity between detector locations, and can serve to improve treatment delivery with implementation in real-time in the surgical setting. We concluded that the standard deviation of light fluence uniformity for this method of pleural PDT is 10%.
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Registered trials
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