Evidence map›Paper›PMID 32053769›Full record

ArticleNeuron2020

Thalamus Modulates Consciousness via Layer-Specific Control of Cortex.

Michelle J Redinbaugh, Jessica M Phillips, Niranjan A Kambi, Sounak Mohanta, Samantha Andryk, Gaven L Dooley, Mohsen Afrasiabi, Aeyal Raz, Yuri B Saalmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  5. Cephalopod Behavior: From Neural Plasticity to Consciousness.Frontiers in systems neuroscience · 2021
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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Michelle J RedinbaughDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: mredinbaugh@wisc.edu.
Jessica M PhillipsDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Niranjan A KambiDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sounak MohantaDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Samantha AndrykDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Gaven L DooleyDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Mohsen AfrasiabiDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Aeyal RazDepartment of Anesthesiology, Rambam Health Care Campus, Haifa 3109601, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
Yuri B SaalmannDepartment of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA; Wisconsin National Primate Research Center, Madison, WI 53715, USA. Electronic address: saalmann@wisc.edu.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Prefrontal cortico-thalamic dynamics in cognitive controlR01MH110311 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI SAALMANN, YURI B · 2016 to 2020
$1.8M
NIH HHS P51 OD011106NIMH NIH HHS R01 MH110311
6 · The paper itself

Abstract

Functional MRI and electrophysiology studies suggest that consciousness depends on large-scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in different cortical layers and circuits contribute. We simultaneously recorded from central lateral thalamus (CL) and across layers of the frontoparietal cortex in awake, sleeping, and anesthetized macaques. We found that neurons in thalamus and deep cortical layers are most sensitive to changes in consciousness level, consistent across different anesthetic agents and sleep. Deep-layer activity is sustained by interactions with CL. Consciousness also depends on deep-layer neurons providing feedback to superficial layers (not to deep layers), suggesting that long-range feedback and intracolumnar signaling are important. To show causality, we stimulated CL in anesthetized macaques and effectively restored arousal and wake-like neural processing. This effect was location and frequency specific. Our findings suggest layer-specific thalamocortical correlates of consciousness and inform how targeted deep brain stimulation can alleviate disorders of consciousness.

Indexed as

Anesthesia, GeneralAnesthetics, InhalationAnesthetics, IntravenousAnimalsCerebral CortexConsciousnessElectric StimulationElectroencephalographyFeedbackFrontal LobeIntralaminar Thalamic NucleiIsofluraneMacacaNeural PathwaysParietal LobePropofolAnesthetics, InhalationAnesthetics, IntravenousIsofluranePropofolanesthesiacentral thalamusconsciousnessdeep brain stimulationfeedbackfeedforwardfrontal cortexoscillationsparietal cortexsleep

Identifiers

PMID32053769
PMCPMC7243351

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.