ArticleThe Journal of nervous and mental disease2020
The Relation Between Posttraumatic Stress Symptom Severity and Startle Potentiation to Predictable and Unpredictable Threat.
Article in The Journal of nervous and mental disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study.Psychopharmacology · 2021Trial
- Severe PTSD symptoms magnify episodic memory-encoding deficits and amygdala-ACC attenuation during unpredictable threat in male combat veterans.Molecular psychiatry · 2026Article
- Psychosocial impacts of a mouse plague and ongoing psychological stress.Scientific reports · 2026Article
- Emotional reactivity and past self-injurious behavior moderate the association between trauma exposure and fearlessness about death.Suicide & life-threatening behavior · 2024Article
- Using what we know about threat reactivity models to understand mental health during the COVID-19 pandemic.Behaviour research and therapy · 2022Article
- Event-related potentials to acoustic startle probes during unpredictable threat are associated with individual differences in intolerance of uncertainty.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Cross-species anxiety tests in psychiatry: pitfalls and promises.Molecular psychiatry · 2022Review
- A way forward for anxiolytic drug development: Testing candidate anxiolytics with anxiety-potentiated startle in healthy humans.Neuroscience and biobehavioral reviews · 2020Review
- Transdiagnostic physiological correlates of unpredictable threat anticipation.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Aberrant threat reactivity has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD); however, the literature on this association is mixed. One factor that may contribute to this inconsistent association is differences in severity of posttraumatic stress symptoms (PTSSs) across studies, but no studies have tested this hypothesis. The relation between PTSD and threat reactivity may also differ between unpredictable threats (U-threats) and predictable threats (P-threats), given burgeoning evidence to support a particular role for aberrant responding to U-threat in PTSD. The present study examined how PTSS severity relates to startle potentiation to U-threat and P-threat in a trauma-exposed community sample (N = 258). There was a negative linear, but not quadratic, relation between PTSS severity and startle potentiation to U-threat, but not P-threat. Blunted defensive responding to U-threat may therefore contribute to higher levels of PTSSs and may represent a novel treatment target for higher levels of PTSSs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.