Evidence map›Paper›PMID 32053551›Full record

ReviewJournal of glaucoma2020

Optical Coherence Tomography Angiography in Glaucoma.

Harsha L Rao, Zia S Pradhan, Min Hee Suh, Sasan Moghimi, Kaweh Mansouri, Robert N Weinreb

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Journal of glaucoma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 104 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 2 pooled it
17.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06457295 completednot on this mapstarted 2024, after this paper: background citation

Impact of Diabetes Mellitus on Retinal Microvasculature in Patients Without Clinical Retinopathy Using Optical Coherence Tomography Angiography

Typeobservational_patient_registrySponsorSohag UniversityRan2024 to 2025Enrolled200ConditionsDiabetic Retinopathy, DRArmsoptical coherence tomography angiography
NCT07298746 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

OCT Angiography Changes of Retinal Microvasculature After Local Anesthesia in Cases Undergoing Cataract Surgery

TypeinterventionalSponsorSohag UniversityRan2025 to 2027Enrolled100ConditionsOCTA Changes With Local AnesthesiaArmsLocal Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML), Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML), Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML), local Anesthesia (retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 2 syntheses or guidelines pooled it, 201 citations in OpenAlex.

  1. Pooled it
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  3. Optical coherence tomography angiography of the macular retina and choroid in glaucoma: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Harsha L RaoNarayana Nethralaya, Hulimavu.
Zia S PradhanNarayana Nethralaya, Rajajinagar, Bengaluru, Karnataka, India.
Min Hee SuhDepartment of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Sasan MoghimiHamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology, University of California, San Diego, CA.
Kaweh MansouriGlaucoma Research Center, Montchoisi Clinic, Swiss Visio, Lausanne, Switzerland.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology, University of California, San Diego, CA.
Narayana Nethralaya · INUniversity of California, San Diego · USInje University Haeundae Paik Hospital · KR

Funding

Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
NEI NIH HHS R01 EY029058
6 · The paper itself

Abstract

Optical coherence tomography angiography (OCTA) is a relatively new, noninvasive, dye-free imaging modality that provides a qualitative and quantitative assessment of the vasculature in the retina and optic nerve head. OCTA also enables visualization of the choriocapillaris, but only in areas of parapapillary atrophy. With OCTA, the movement of red blood cells is used as a contrast to delineate blood vessels from static tissues. The features seen with OCTA in eyes with glaucoma are reduction in the superficial vessel density in the peripapillary and macular areas, and complete loss of choriocapillaris in localized regions of parapapillary atrophy (called deep-layer microvascular dropout). These OCTA changes correlate well topographically with the functional changes seen on visual field examination and structural changes seen on optical coherence tomography (OCT) (ie, parapapillary retinal nerve fiber layer changes and inner retinal layer thickness changes at macula). The OCTA measurements also have acceptable test-retest variability and well differentiate glaucomatous from normal eyes. OCTA measurements can be affected by various subject-related, eye-related, and disease-related factors. Vessel density reduction on OCTA reaches a base level (floor) at a more advanced disease stage than the structural changes on OCT and therefore has the potential to monitor progression in eyes with advanced glaucomatous damage. OCTA also adds information about glaucoma patients at risk of faster progression. OCTA, therefore, complements visual field and OCT examinations to diagnose glaucoma, detect progression, and assess risk of progression.

Indexed as

AngiographyTomography, Optical CoherenceGlaucoma, Open-AngleHumansIntraocular PressureNerve FibersOptic DiskRetinal Ganglion CellsRetinal VesselsVisual Field Tests

Identifiers

PMID32053551
PMCPMC7117982
OpenAlexW3005817113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.