Evidence map›Paper›PMID 32053109›Full record

ArticleeLife2020

Regulation of mRNA translation by a photoriboswitch.

Kelly A Rotstan, Michael M Abdelsayed, Luiz Fm Passalacqua, Fabio Chizzolini, Kasireddy Sudarshan, A Richard Chamberlin, Jiří Míšek, Andrej Luptak

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Rapid discovery of functional RNA domains.Nucleic acids research · 2025
    Article
  7. Article
  8. Optogenetic Tools for Regulating RNA Metabolism and Functions.Chembiochem : a European journal of chemical biology · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Molecular photoswitches in aqueous environments.Chemical Society reviews · 2021
    Review
  14. Article
  15. Stiff-Stilbene Photoswitches: From Fundamental Studies to Emergent Applications.Angewandte Chemie (International ed. in English) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kelly A Rotstan *Department of Pharmaceutical Sciences, University of California, Irvine, United States.ORCID 0000-0002-2189-4643
Michael M Abdelsayed *Department of Molecular Biology and Biochemistry, University of California, Irvine, United States.ORCID 0000-0002-9622-832X
Luiz Fm PassalacquaDepartment of Pharmaceutical Sciences, University of California, Irvine, United States.ORCID 0000-0002-5490-2427
Fabio ChizzoliniDepartment of Pharmaceutical Sciences, University of California, Irvine, United States.ORCID 0000-0003-4455-8367
Kasireddy SudarshanDepartment of Organic Chemistry, Charles University, Prague, Czech Republic.ORCID 0000-0002-7072-3226
A Richard ChamberlinDepartment of Pharmaceutical Sciences, University of California, Irvine, United States.ORCID 0000-0002-4685-4672
Jiří MíšekDepartment of Pharmaceutical Sciences, University of California, Irvine, United States.ORCID 0000-0003-4645-7113
Andrej LuptakDepartment of Pharmaceutical Sciences, University of California, Irvine, United States.ORCID 0000-0002-0632-5442
University of California, Irvine · USCharles University · CZ

Funding

Luminescent RNAsR01GM094929 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LUPTAK, ANDREJ · 2010 to 2013
$1.2M
Training Program in Chemical and Structural BiologyT32GM108561 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI POULOS, THOMAS L, TOBIAS, DOUGLAS J · 2014 to 2018
$860k
NIGMS NIH HHS R01 GM094929NIGMS NIH HHS T32 GM108561
6 · The paper itself

Abstract

Optogenetic tools have revolutionized the study of receptor-mediated processes, but such tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs are needed for spatiotemporal control of gene expression. To fill this gap, we used in vitro selection to isolate a novel riboswitch that selectively binds the

Indexed as

Protein BiosynthesisRiboswitchEscherichia coliGene Expression Regulation, BacterialRNA, BacterialRNA, MessengerSpectrum AnalysisRiboswitchRNA, BacterialRNA, Messengeraptamerbiochemistrychemical biologyE. coliluciferasephotoregulationriboswitchstilbenetranslation initiation

Identifiers

PMID32053109
PMCPMC7051177
OpenAlexW3005913027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.