Evidence map›Paper›PMID 32052896›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases.

Shasha Li, Sean A Newmister, Andrew N Lowell, Jiachen Zi, Callie R Chappell, Fengan Yu, Robert M Hohlman, Jimmy Orjala, Robert M Williams, David H Sherman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shasha LiLife Sciences Institute, Department of Medicinal Chemistry, The University of Michigan, USA.ORCID 0000-0001-7468-0377
Sean A NewmisterLife Science Institute, The University of Michigan, USA.
Andrew N LowellLife Science Institute, The University of Michigan, USA.
Jiachen ZiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Callie R ChappellDepartment of Molecular, Cellular & Developmental Biology, The University of Michigan, USA.
Fengan YuLife Science Institute, The University of Michigan, USA.
Robert M HohlmanLife Sciences Institute, Department of Medicinal Chemistry, The University of Michigan, USA.
Jimmy OrjalaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Robert M WilliamsDepartment of Chemistry, Colorado State University, Fort Collins, CO, 80523, USA.
David H ShermanLife Sciences Institute, Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, The University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109-2216n, USA.ORCID 0000-0001-8334-3647
University of Michigan · USUniversity of Illinois Chicago · USUniversity of Colorado Cancer Center · US

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JAMES R FUCHS · 2007 to 2026
$27.2M
Discovery and Characterization of Natural Product Systems-Research Supplement to Promote DiversityR35GM118101 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHERMAN, DAVID H · 2016 to 2025
$3.3M
NCI NIH HHS P01 CA125066NIGMS NIH HHS R35 GM118101
6 · The paper itself

Abstract

Stereospecific polycyclic core formation of hapalindoles and fischerindoles is controlled by Stig cyclases through a three-step cascade involving Cope rearrangement, 6-exo-trig cyclization, and a final electrophilic aromatic substitution. Reported here is a comprehensive study of all currently annotated Stig cyclases, revealing that these proteins can assemble into heteromeric complexes, induced by Ca

Indexed as

Bacterial ProteinsCalciumCyanobacteriaCyclizationIndole AlkaloidsIndolesLyasesStereoisomerismBacterial ProteinsCalciumhapalindole UIndole AlkaloidsIndolesLyasesbiocatalysiscyclasesindolesoligomerizationrearrangements

Identifiers

PMID32052896
PMCPMC7274885
OpenAlexW3005597070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.