Evidence map›Paper›PMID 32052466›Full record

SynthesisJournal of medical virology2020

Potential interventions for novel coronavirus in China: A systematic review.

Lei Zhang, Yunhui Liu

8 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 566 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
566citing papers in PubMed, 4 pooled it
33.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04334512 phase2completednot on this map

A Randomized, Double-Blind, Placebo-Controlled Phase IIa Study of Quintuple Therapy to Treat COVID-19 Infection

TypeinterventionalSponsorProgenaBiomeRan2020 to 2024Enrolled118ConditionsCOVID-19, Corona Virus Infection, Coronavirus-19, Sars-CoV2ArmsHydroxychloroquine, Azithromycin, Vitamin C, Vitamin D, Zinc
NCT04335084 phase2completednot on this map

A Randomized, Double-Blind, Placebo-Controlled Phase IIa Study of Hydroxychloroquine, Vitamin C, Vitamin D, and Zinc for the Prevention of COVID-19 Infection

TypeinterventionalSponsorProgenaBiomeRan2020 to 2024Enrolled254ConditionsCOVID-19, Coronavirus Infection, Sars-CoV2, Corona Virus InfectionArmsHydroxychloroquine, Vitamin C, Vitamin D, Zinc
NCT04358783 phase2completednot on this map

Phase II, Randomized, Double-blind, Controlled Clinical Trial Evaluating the Efficacy and Safety of Plasma From Patients Cured of COVID-19 Compared to the Best Available Therapy in Subjects With SARS-CoV-2 Pneumonia

TypeinterventionalSponsorHospital Universitario Dr. Jose E. GonzalezRan2020 to 2021Enrolled31ConditionsCoronavirus InfectionArmsPlasma, Best Available Therapy
NCT04367883 recruitingnot on this map

Evaluation of Influenza Vaccination and Treatment With ACEI and ARB in the Evolution of SARS-CoV2 Infection

TypeobservationalSponsorConsorci Sanitari de TerrassaRan2020 to 2028Enrolled3,000ConditionsCOVID19, Influenza Vaccination, ACE Inhibitors, ARBArmsAntihistamine, Amantadine, ACEI, ARB, Influenza vaccine and COVID
NCT04447144 unknown statusnot on this map

Nutritional Habits, Does it Affect Coronavirus Disease 2019 (COVID-19) Infection Outcome? An Egyptian Experience

TypeobservationalSponsorCairo UniversityRan2020 to 2020Enrolled200ConditionsCovid19, Chronic Inflammation, Non-Communicable Chronic Diseases
NCT04516811 phase3terminatednot on this map

A Prospective, Randomized, Placebo-controlled, Double-blinded, Phase III Clinical Trial of the Therapeutic Use of Convalescent Plasma in the Treatment of Patients With Moderate to Severe COVID-19

TypeinterventionalSponsorSouth African National Blood ServiceRan2020 to 2022Enrolled102ConditionsCOVID-19, SARS-CoV-2 Infection, Severe Acute Respiratory Syndrome Coronavirus 2ArmsCOVID-19 convalescent plasma (CCP) plus standard of care (SOC), Standard of care (SOC) plus placebo
NCT04602507 phase2terminatednot on this map

Ivermectin in Adults With Severe COVID-19. Double-blind Randomized Clinical Trial

TypeinterventionalSponsorCES UniversityRan2020 to 2021Enrolled75ConditionsCovid19, Severe Acute Respiratory SyndromeArmsIvermectin, Placebo
NCT05178225 nacompletednot on this mapstarted 2021, after this paper: background citation

Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome

TypeinterventionalSponsorComenius UniversityRan2021 to 2022Enrolled51ConditionsCOVID-19 Respiratory InfectionArmsubiquinol (reduced coenzyme Q10), mountain spa rehabilitation, 2x14 ml of peripheral blood collected in a tube with anticoagulant
3 · Its place in the literature

Who cites it

566 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,384 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. What you need to know about children's COVID-19: a systematic review.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. The "Magnificent Seven" in Oral and Systemic Health against COVID-19.Endocrine, metabolic & immune disorders drug targets · 2025
    Review
  16. Article
  17. Nitric Oxide Signaling and Sensing in Age-Related Diseases.Antioxidants (Basel, Switzerland) · 2024
    Review
  18. Review
  19. Article
  20. Review

506 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lei ZhangDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Yunhui LiuDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.ORCID 0000-0002-9920-9933
China Medical University · CN

Funding

Project of Key Laboratory of Neurooncology in Liaoning Province, China 112-2400017005
6 · The paper itself

Abstract

An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. We suggest that the nutritional status of each infected patient should be evaluated before the administration of general treatments and the current children's RNA-virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers. In addition, convalescent plasma should be given to COVID-19 patients if it is available. In conclusion, we suggest that all the potential interventions be implemented to control the emerging COVID-19 if the infection is uncontrollable.

Indexed as

Immunization, PassiveNutritional StatusAntiviral AgentsBetacoronavirusChinaCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentCOVID-19 SerotherapyCOVID-19 VaccinesHumansImmunologic FactorsPlasmaPneumonia, ViralSARS-CoV-2Trace ElementsAntiviral AgentsCOVID-19 VaccinesImmunologic FactorsTrace ElementsViral VaccinesVitamins2019-CoVcoronavirusCOVID-19MERSpotential interventionsSARS

Identifiers

PMID32052466
PMCPMC7166986
OpenAlexW3006252254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.