Evidence map›Paper›PMID 32052462›Full record

Trial reportJournal of clinical pharmacology2020

Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease-A Pilot Study.

Abhishek G Sathe, Paul Tuite, Chi Chen, Yiwei Ma, Wei Chen, James Cloyd, Walter C Low, Clifford J Steer, Byeong-Yeul Lee, Xiao-Hong Zhu and 1 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 35 citations in OpenAlex.

  1. A Double-Blind, Randomized, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023
    Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Neuroprotection in Parkinson Disease.Neurology and therapy · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review).International journal of molecular medicine · 2024
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Abhishek G SatheCenter for Orphan Drug Research and Department of Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, Minnesota, USA.
Paul TuiteDepartment of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Chi ChenDepartment of Food Science and Nutrition, College of Food, Agricultural and Natural Resource Sciences, University of Minnesota, St. Paul, Minnesota, USA.
Yiwei MaDepartment of Food Science and Nutrition, College of Food, Agricultural and Natural Resource Sciences, University of Minnesota, St. Paul, Minnesota, USA.
Wei ChenCenter for Magnetic Resonance Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
James CloydCenter for Orphan Drug Research and Department of Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, Minnesota, USA.
Walter C LowDepartment of Neurosurgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Clifford J SteerDepartments of Medicine and Genetics, Cell Biology and Development, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Byeong-Yeul LeeCenter for Magnetic Resonance Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Xiao-Hong ZhuCenter for Magnetic Resonance Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Lisa D ColesCenter for Orphan Drug Research and Department of Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, Minnesota, USA.
University of Minnesota · USUniversity of Minnesota Medical Center · USResonance Research (United States) · US

Funding

Breaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and NeuroenergeticsU01EB026978 · NIBIB · UNIVERSITY OF MINNESOTA · PI CHEN, WEI, ZHU, XIAO-HONG · 2018 to 2022
$6.4M
NIBIB NIH HHS U01 EB026978
6 · The paper itself

Abstract

Mitochondrial dysfunction is implicated in the pathogenesis of Parkinson's disease. Preliminary data have shown lower brain adenosine triphosphate (ATP) levels in Parkinson's disease versus age-matched healthy controls. Ursodeoxycholic acid (UDCA) may improve impaired mitochondrial function. Our objective was to evaluate UDCA tolerability, pharmacokinetics, and its effect on brain bioenergetics in individuals with Parkinson's disease. An open-label, prospective, multiple-ascending-dose study of oral UDCA in 5 individuals with Parkinson's disease was completed. A blood safety panel, plasma concentrations of UDCA and UDCA conjugates, and brain ATP levels were measured before and after therapy (week 1: 15 mg/kg/day; week 2: 30 mg/kg/day; and weeks 3-6: 50 mg/kg/day). UDCA and conjugates were measured using liquid chromatography-mass spectrometry. ATP levels and ATPase activity were measured using 7-Tesla

Indexed as

Adenosine TriphosphateAdministration, OralAgedBrainCognitionDrug Administration ScheduleFemaleGastrointestinal DiseasesHumansMagnetic Resonance ImagingMaleMental Status and Dementia TestsMiddle AgedNeuroprotective AgentsParkinson DiseasePilot ProjectsAdenosine TriphosphateNeuroprotective AgentsUrsodeoxycholic Acidbrain bioenergeticsmitochondrial dysfunctionMRSParkinson's diseasepharmacokineticsursodeoxycholic acid

Identifiers

PMID32052462
PMCPMC7245554
OpenAlexW3006385761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.