Evidence map›Paper›PMID 32052458›Full record

ArticleMuscle & nerve2020

Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer.

Thomas W Lycan, Fang-Chi Hsu, Christine S Ahn, Alexandra Thomas, Francis O Walker, Omar P Sangueza, Yusuke Shiozawa, Sun Hee Park, Christopher M Peters, Edgar Alfonso Romero-Sandoval and 6 more

Abstract read
In one paragraph

Article in Muscle & nerve, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Musculoskeletal Ultrasound and MRI in the Evaluation of Chemotherapy-Induced Peripheral Neuropathy: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Nerve Ultrasound as Helpful Tool in Polyneuropathies.Diagnostics (Basel, Switzerland) · 2021
    Review
  11. Review
  12. Nerve cross-sectional area in vincristine-induced polyneuropathy: A nerve ultrasound pilot study.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thomas W LycanInternal Medicine: Hematology and Oncology, Wake Forest School of Medicine, North Carolina.ORCID 0000-0001-9475-1558
Fang-Chi HsuBiostatistics and Data Science, Wake Forest School of Medicine, North Carolina.
Christine S AhnDermatology, Wake Forest School of Medicine, North Carolina.
Alexandra ThomasInternal Medicine: Hematology and Oncology, Wake Forest School of Medicine, North Carolina.
Francis O WalkerNeurology, Wake Forest School of Medicine, North Carolina.
Omar P SanguezaPathology, Wake Forest School of Medicine, North Carolina.
Yusuke ShiozawaCancer Biology, Wake Forest School of Medicine, North Carolina.
Sun Hee ParkCancer Biology, Wake Forest School of Medicine, North Carolina.
Christopher M PetersCancer Biology, Wake Forest School of Medicine, North Carolina.
Edgar Alfonso Romero-SandovalAnesthesiology, Wake Forest School of Medicine, North Carolina.
Susan A MelinInternal Medicine: Hematology and Oncology, Wake Forest School of Medicine, North Carolina.
Steven SorscherInternal Medicine: Hematology and Oncology, Wake Forest School of Medicine, North Carolina.
Katherine AnsleyInternal Medicine: Hematology and Oncology, Wake Forest School of Medicine, North Carolina.
Glenn J LesserInternal Medicine: Hematology and Oncology, Wake Forest School of Medicine, North Carolina.
Michael S CartwrightNeurology, Wake Forest School of Medicine, North Carolina.
Roy E StrowdNeurology, Wake Forest School of Medicine, North Carolina.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
The contributions of sensory nerves to bone metastasis and associated bone painR01CA238888 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHIOZAWA, YUSUKE · 2020 to 2024
$1.8M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA238888
6 · The paper itself

Abstract

backgroundOur study aim was to evaluate neuromuscular ultrasound (NMUS) for the assessment of taxane chemotherapy-induced peripheral neuropathy (CIPN), the dose-limiting toxicity of this agent.

methodsThis cross-sectional study of breast cancer patients with taxane CIPN measured nerve cross-sectional area (CSA) by NMUS and compared with healthy historical controls. Correlations were determined between CSA and symptom scale, nerve conduction studies, and intraepidermal nerve fiber density (IENFD).

resultsA total of 20 participants reported moderate CIPN symptoms at a median of 3.8 months following the last taxane dose. Sural nerve CSA was 1.2 mm

conclusionsThese data support a sensory predominant taxane neuropathy or neuronopathy and warrant future research on longitudinal NMUS assessment of CIPN.

Indexed as

AgedAlbuminsAnkleAntineoplastic AgentsBreast NeoplasmsCross-Sectional StudiesDocetaxelElectrodiagnosisEpidermisFemaleForearmHumansLegMedian NerveMiddle AgedNerve Fibers130-nm albumin-bound paclitaxelAlbuminsAntineoplastic AgentsDocetaxelPaclitaxelTaxoidsbreast cancerchemotherapyneuropathytaxaneultrasound

Identifiers

PMID32052458
PMCPMC8247453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.