Evidence map›Paper›PMID 32052382›Full record

SynthesisClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2020

Review of concepts in therapeutic decision-making in HER2-negative luminal metastatic breast cancer.

I Alvarez-Lopez, S Bezares, E Dalmau Portulas, E García-Martínez, J Á García-Sáenz, M Gil-Gil, E Martínez de Dueñas, N Ribelles, A Santaballa Bertrán

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 1 country.

I Alvarez-LopezHospital Universitario Donostia-BioDonostia, Begiristain Doktorea Pasealekua, 109, 20014, Donostia, Gipuzkoa, Spain. isabelmanuela.alvarezlopez@osakidetza.eus.ORCID http://orcid.org/0000-0001-8958-0694
S BezaresGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
E Dalmau PortulasGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
E García-MartínezGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
J Á García-SáenzGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
M Gil-GilGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
E Martínez de DueñasGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
N RibellesGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
A Santaballa BertránGrupo GEICAM de Investigación en Cáncer de Mama/GEICAM Spanish Breast Cancer Group, San Sebastián de los Reyes, Madrid, Spain.
Bellvitge University Hospital · ESBiogipuzkoa Health Research Institute · ESConsorcio Hospitalario Provincial de Castellón · ESGEICAM – Spanish Breast Cancer Group · ESHospital de Sabadell · ESHospital General Universitario Morales Meseguer · ESHospital Regional Universitario de Málaga · ESHospital Universitari i Politècnic La Fe · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHormone receptor (HR)-positive, Human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) requires a therapeutic approach that takes into account multiple factors, with treatment being based on anti-estrogen hormone therapy (HT). As consensus documents are valuable tools that assist in the decision-making process for establishing clinical strategies and optimize the delivery of health services, this consensus document has been created with the aim of developing recommendations on cretiera for hormone sensitivity and resistance in HER2-negative luminal MBC and facilitating clinical decision-making.

methodsThis consensus document was generated using a modification of the RAND/UCLA methodology, which included the definition of the project and identification of issues of interest, a non-exhaustive systematic review of the literature, an analysis and synthesis of the scientific evidence, preparation of recommendations, and external evaluation with a panel of 64 medical oncologists specializing in breast cancer.

resultsA Spanish panel of experts reached consensus on 32 of the 32 recommendations/conclusions presented in the first round and were accepted with an approval rate of 100% about definition of metastatic disease not susceptible to local curative treatment, definition of hormone sensitivity and hormone resistance in metastatic luminal disease and therapeutic decision-making.

conclusionWe have developed a consensus document with recommendations on the treatment of patients with HER2-negative luminal MBC that will help to improve therapeutic benefits.

Indexed as

Clinical Decision-MakingConsensusErb-b2 Receptor Tyrosine KinasesAgedAntineoplastic Agents, HormonalBiomarkers, TumorBiopsyBreastBreast NeoplasmsDrug Resistance, NeoplasmFemaleGene ExpressionHumansImmunohistochemistryKi-67 AntigenMenopauseAntineoplastic Agents, HormonalBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesKi-67 AntigenReceptors, EstrogenReceptors, ProgesteroneConsensusHormonal receptorHormonal resistanceHormonal therapyLuminalMetastatic breast cancer

Identifiers

PMID32052382
PMCPMC7316841
OpenAlexW3006220030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.