Evidence map›Paper›PMID 32052254›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2020

Baroreflex activation therapy reduces frequency and duration of hypertension-related hospitalizations in patients with resistant hypertension.

Marcel Halbach, David Grothaus, Fabian Hoffmann, Navid Madershahian, Kathrin Kuhr, Hannes Reuter

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Key challenges in exploring the rat as a preclinical neurostimulation model for aortic baroreflex modulation in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marcel HalbachDepartment of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. marcel.halbach@uk-koeln.de.ORCID http://orcid.org/0000-0002-6361-5825
David GrothausDepartment of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Fabian HoffmannDepartment of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Navid MadershahianDepartment of Cardiac Surgery, University of Cologne, Cologne, Germany.
Kathrin KuhrInstitute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
Hannes ReuterDepartment of Internal Medicine III, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBaroreflex activation therapy (BAT) has been shown to lower blood pressure in patients with resistant hypertension. The purpose of this study was to analyze whether this translates into a reduction of more relevant clinical endpoints.

methodsPatients with resistant hypertension were treated with the second-generation BAT system. Records on hospitalization (dates of admission and discharge, main diagnosis) were obtained from medical insurance companies.

resultsRecords on hospitalization were available for a period of 1 year before BAT in two patients and 2 years in 22 patients. The total number of hospitalizations per patient was 3.3 ± 3.5/year before BAT and 2.2 ± 2.7/year after BAT (p = 0.03). Hospitalizations related to hypertension were significantly decreased from 1.5 ± 1.6/year before BAT to 0.5 ± 0.9/year after BAT (p < 0.01). The cumulative duration of hypertension-related hospital stays was significantly reduced from 8.0 ± 8.7 days/year before BAT to 1.8 ± 4.8 days/year after BAT (p < 0.01). Office cuff blood pressure was 183 ± 27 mmHg over 102 ± 17 mmHg under 6.6 ± 2.0 antihypertensive drugs before BAT and 157 ± 32 mmHg over 91 ± 20 mmHg (both p < 0.01) under 5.9 ± 1.9 antihypertensive drugs (p = 0.09 for number of drugs) at latest follow-up. Daytime ambulatory blood pressure was 164 ± 21 mmHg over 91 ± 14 mmHg before BAT and 153 ± 21 mmHg (p = 0.03) over 89 ± 15 mmHg (p = 0.56) at latest follow-up. Heart rate was 75 ± 16 bpm before BAT and 72 ± 12 bpm at latest follow-up (p = 0.35).

conclusionsRate and duration of hypertension-related hospitalizations in patients with severe resistant hypertension were lowered after BAT. Whether the response is mediated through improvements in blood pressure control requires further studies.

Indexed as

BaroreflexHypertensionAntihypertensive AgentsBlood PressureBlood Pressure Monitoring, AmbulatoryHospitalizationHumansAntihypertensive AgentsBaroreflexHospitalizationHypertensionMedical deviceResistant hypertension

Identifiers

PMID32052254
PMCPMC8302539
OpenAlexW3006092817

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.