Evidence map›Paper›PMID 32052204›Full record

SynthesisCurrent oncology reports2020

Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence.

Shinya Matsuzaki, Maximilian Klar, Mikio Mikami, Muneaki Shimada, Brendan H Grubbs, Keiichi Fujiwara, Lynda D Roman, Koji Matsuo

Open access · greenAbstract readComparative StudySystematic Review
In one paragraph

Synthesis in Current oncology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Shinya MatsuzakiDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, 2020 Zonal Avenue IRD520, Los Angeles, CA, 90033, USA.
Maximilian KlarDepartment of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany.
Mikio MikamiDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Muneaki ShimadaDepartment of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Brendan H GrubbsDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
Keiichi FujiwaraDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Lynda D RomanDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, 2020 Zonal Avenue IRD520, Los Angeles, CA, 90033, USA.
Koji MatsuoDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, 2020 Zonal Avenue IRD520, Los Angeles, CA, 90033, USA. koji.matsuo@med.usc.edu.
University of Southern California · USSaitama Medical University · JPTohoku University · JPTokai University · JPUniversity of Freiburg · DE

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

purpose of reviewTo review and discuss the present evidence of surgery- and radiation-based treatment strategies for stage IIB cervical cancer. RECENT

findingsRecently, two randomized controlled trials compared the efficacy of neoadjuvant chemotherapy followed by radical hysterectomy (NACT + RH) with that of concurrent chemoradiotherapy (CCRT) for stage IB3-IIB cervical cancer. When these studies were combined (N = 1259), NACT + RH was associated with a shorter disease-free survival [hazard ratio (HR) 1.36, 95% confidence interval (CI) 1.13-1.64], but with a similar overall survival (HR 1.11, 95% CI 0.90-1.36) when compared with the findings for CCRT. Stage-specific analysis for stage IIB cervical cancer demonstrated that disease-free survival was significantly worse with NACT + RH than with CCRT (HR 1.90, 95% CI 1.25-2.89); however, no significant difference was observed for stage IB3-IIA cervical cancer. Based on the results of recent level I evidence, the standard treatment for stage IIB cervical cancer remains CCRT.

Indexed as

ChemoradiotherapyHysterectomyNeoadjuvant TherapyAdenocarcinomaAntineoplastic AgentsCarcinoma, AdenosquamousCarcinoma, Squamous CellCombined Modality TherapyFemaleHumansNeoplasm StagingPractice Guidelines as TopicPrognosisRandomized Controlled Trials as TopicUterine Cervical NeoplasmsAntineoplastic AgentsCervical cancerConcurrent chemoradiotherapyNeoadjuvant chemotherapyRadical hysterectomyStage IISurvival

Identifiers

PMID32052204
PMCPMC7759090
OpenAlexW3006572148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.