ArticleThe Journal of infectious diseases2020
A Protein Epitope Targeted by the Antibody Response to Kawasaki Disease.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Pooled it
- Kawasaki disease recurrence in the COVID-19 era: a systematic review of the literature.Italian journal of pediatrics · 2021Pooled it
- Bioinformatics identification of mitochondrial dynamics-related potential biomarkers in kawasaki disease and prediction of potential regulatory correlations.Frontiers in cardiovascular medicine · 2026Article
- Potential Mechanisms and Hypotheses for Pathogenic Microorganisms Triggering Kawasaki Disease.Clinical reviews in allergy & immunology · 2025Review
- Monoclonal Antibodies From Children With Acute Kawasaki Disease Identify a Common Antigenic Target in Fatal Cases Over 5 Decades.Laboratory investigation; a journal of technical methods and pathology · 2025Article
- The etiologies of Kawasaki disease.The Journal of clinical investigation · 2024Review
- Analysis of Plasmablasts From Children With Kawasaki Disease Reveals Evidence of a Convergent Antibody Response to a Specific Protein Epitope.The Journal of infectious diseases · 2023Article
- Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: Common Inflammatory Pathways of Two Distinct Diseases.Rheumatic diseases clinics of North America · 2023Review
- Diagnostic model based on bioinformatics and machine learning to distinguish Kawasaki disease using multiple datasets.BMC pediatrics · 2022Article
- Gut Microbiota Dysbiosis in Childhood Vasculitis: A Perspective Comparative Pilot Study.Journal of personalized medicine · 2022Article
- Epidemiological and Clinical Features of Kawasaki Disease During the COVID-19 Pandemic in the United States.JAMA network open · 2022Article
- An Unintended Consequence of Pandemic Control Measures: Fewer Cases of Kawasaki Disease.The Journal of pediatrics · 2021Article
- Kawasaki Disease and Pediatric Infectious Diseases During the Coronavirus Disease 2019 Pandemic.The Journal of pediatrics · 2021Article
- Article
- COVID-19 Disease, Women's Predominant Non-Heparin Vaccine-Induced Thrombotic Thrombocytopenia and Kounis Syndrome: A Passepartout Cytokine Storm Interplay.Biomedicines · 2021Review
- SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?The Journal of experimental medicine · 2021Review
- [COVID-19 in children: SARS-CoV-2-related inflammatory multisystem syndrome mimicking Kawasaki disease].Bulletin de l'Academie nationale de medecine · 2021Review
- Diagnosing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Related Multisystem Inflammatory Syndrome in Children (MIS-C): Focus on the Gastrointestinal Tract and the Myocardium.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children mimicking Kawasaki disease.Archives of cardiovascular diseases · 2021Review
- Oral manifestations of COVID-2019-related multisystem inflammatory syndrome in children: a review of 47 pediatric patients.Journal of the American Dental Association (1939) · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundKawasaki disease (KD) is the leading cause of childhood acquired heart disease in developed nations and can result in coronary artery aneurysms and death. Clinical and epidemiologic features implicate an infectious cause but specific antigenic targets of the disease are unknown. Peripheral blood plasmablasts are normally highly clonally diverse but the antibodies they encode are approximately 70% antigen-specific 1-2 weeks after infection.
methodsWe isolated single peripheral blood plasmablasts from children with KD 1-3 weeks after onset and prepared 60 monoclonal antibodies (mAbs). We used the mAbs to identify their target antigens and assessed serologic response among KD patients and controls to specific antigen.
resultsThirty-two mAbs from 9 of 11 patients recognize antigen within intracytoplasmic inclusion bodies in ciliated bronchial epithelial cells of fatal cases. Five of these mAbs, from 3 patients with coronary aneurysms, recognize a specific peptide, which blocks binding to inclusion bodies. Sera from 5/8 KD patients day ≥ 8 after illness onset, compared with 0/17 infant controls (P < .01), recognized the KD peptide antigen.
conclusionsThese results identify a protein epitope targeted by the antibody response to KD and provide a means to elucidate the pathogenesis of this important worldwide pediatric problem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.