Evidence map›Paper›PMID 32051760›Full record

ArticleRSC advances2014

A self-internalizing mitochondrial TSPO targeting imaging probe for fluorescence, MRI and EM.

Lynn E Samuelson, Bernard M Anderson, Mingfeng Bai, Madeline J Dukes, Colette R Hunt, Jonathon D Casey, Zeqiu Han, Vassilios Papadopoulos, Darryl J Bornhop

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles.International journal of molecular sciences · 2019
    Article
  3. Article
  4. Photostable, hydrophilic, and near infrared quaterrylene-based dyes for photoacoustic imaging.Materials science & engineering. C, Materials for biological applications · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lynn E SamuelsonDepartment of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235-1822, USA.
Bernard M AndersonDepartment of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235-1822, USA.
Mingfeng BaiDepartment of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235-1822, USA.
Madeline J DukesDepartment of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235-1822, USA.
Colette R HuntDepartment of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235-1822, USA.
Jonathon D CaseyDepartment of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235-1822, USA.
Zeqiu HanDepartment of Biochemistry &Molecular and Ceilular Biology, Georgetown University Medical Center, BSB Room 315, 3900 Reservoir Road NW, Washington, DC 20057, USA.
Vassilios PapadopoulosThe Research Institute of the McGill University Health Centre, Departments of Medicine, Biochemistry, and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Darryl J BornhopDepartment of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235-1822, USA.
Vanderbilt University · USGeorgetown University · USMcGill University Health Centre · CA

Funding

Probes:Quantitative Optical and Electron Microscopy(RMI)P20GM072048 · NIGMS · VANDERBILT UNIVERSITY · PI PISTON, DAVID W. · 2004 to 2007
$2.7M
NIGMS NIH HHS P20 GM072048
6 · The paper itself

Abstract

Advances in probes for cellular imaging have driven discoveries in biology and medicine. Primarily, antibodies and small molecules have been made for contrast enhancement of specific proteins. The development of new dendrimer-based tools offers opportunities to tune cellular internalization and targeting, image multiple modalities in the same molecule and explore therapeutics. The translocator protein (TSPO) offers an ideal target to develop dendrimer tools because it is well characterized and implicated in a number of disease states. The TSPO-targeted dendrimers reported here, primarily ClPhIQ-PAMAM-Gd-Liss, are cell membrane permeable nanoparticles that enable labeling of TSPO and provide contrast in fluorescence, electron microscopy and magnetic resonance imaging. The molecular binding affinity for TSPO was found to be 0.51 μM, 3 times greater than the monomeric agents previously demonstrated in our laboratory. The relaxivity per Gd

Identifiers

PMID32051760
PMCPMC7015156
OpenAlexW2153296784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.