Evidence map›Paper›PMID 32051738›Full record

ArticleAmerican journal of translational research2020

Tartary buckwheat extract alleviates alcohol-induced acute and chronic liver injuries through the inhibition of oxidative stress and mitochondrial cell death pathway.

Qiang Yang, Chengliang Luo, Xinmu Zhang, Yuancai Liu, Zufeng Wang, Piergiacomo Cacciamani, Jiao Shi, Yongchun Cui, Chunling Wang, Bharati Sinha and 13 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Tartary Buckwheat in Human Nutrition.Plants (Basel, Switzerland) · 2021
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Qiang YangHubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute Daye, Hubei, China.
Chengliang LuoBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Xinmu ZhangBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Yuancai LiuHubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute Daye, Hubei, China.
Zufeng WangBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Piergiacomo CacciamaniBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Jiao ShiHubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute Daye, Hubei, China.
Yongchun CuiBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Chunling WangBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Bharati SinhaBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Bin PengBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Guoqiang TongHubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute Daye, Hubei, China.
Gapika DasBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Elisha ShahBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Yuan GaoDepartments of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Wei LiBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Yanyang TuBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Dongyang QianDepartments of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Khalid ShahBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Mohammed AkbarDivision of Neuroscience & Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Rockville, MD, USA.
Shuanhu ZhouDepartments of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Byoung-Joon SongSection of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health Rockville, MD, USA.
Xin WangBrigham and Women's Hospital, Harvard Medical School Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USNational Institute on Alcohol Abuse and Alcoholism · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol use disorder (AUD) is an enormous public health problem that poses significant social, medical, and economic burdens. Under AUD, the liver is one of the most adversely affected organs. As current therapies and protective drugs for AUD-mediated liver injury are very limited, the prevention and therapy of alcoholic liver disease are urgently needed. The present study aims to investigate the beneficial effects of tartary buckwheat extract (TBE), the important component of Maopu tartary buckwheat liquor, on both alcoholic-induced acute and chronic liver injuries. We show that the TBE administration, similar to curcumin, significantly reduces the elevated serum aspartate aminotransferase and alanine aminotransferase levels, improves liver index, alleviates the elevated contents of hepatic malondialdehye, and restores the decreased contents of hepatic glutathione both in acute and chronic liver injuries in alcohol-exposed rats. Furthermore, histopathological analyses show that a medium dose of TBE (16.70 ml/kg body weight) alleviates hepatocyte morphology changes in both acute and chronic alcohol exposure models. We also show the protective effects of TBE on the cell death rates of alcohol-exposed primary cultured hepatocytes, HepG2 hepatoma, and Huh 7 hepatoma cells. Furthermore, we demonstrate that TBE exerts hepatoprotection partly through inhibiting the mitochondrial cell death pathway by reducing cytochrome c release, caspase-9 and -3 activities, and the number of TUNEL-positive cells. These effects of TBE were accompanied by enhanced levels of Bcl-2 and Bcl-xL and autophagic cell death pathway by reducing Beclin-1 expression, as well as through promoting its anti-oxidant capacity by suppressing reactive oxygen species production. This study demonstrates, for the first time, the protective effect of TBE against alcohol-induced acute and chronic liver injury

Indexed as

alcoholic liver injuriesmitochondrial cell deathoxidative stressTartary buckwheat extract (TBE)

Identifiers

PMID32051738
PMCPMC7013218
OpenAlexW3008720363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.