Evidence map›Paper›PMID 32051731›Full record

ArticleOxidative medicine and cellular longevity2020

Exosome-Mediated Transfer of ACE2 (Angiotensin-Converting Enzyme 2) from Endothelial Progenitor Cells Promotes Survival and Function of Endothelial Cell.

Jinju Wang, Shuzhen Chen, Ji Bihl

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed.

  1. Review
  2. ACE2: Friend or Foe in Post-COVID-19 Neurodegeneration?International journal of molecular sciences · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Exosomes in arteriovenous fistula stenosis.Frontiers in cell and developmental biology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  17. Review
  18. Review
  19. Review
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jinju WangDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.ORCID https://orcid.org/0000-0003-1210-7676
Shuzhen ChenDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.
Ji BihlDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.ORCID https://orcid.org/0000-0003-2404-1782

Funding

Exosomes from miR-primed endothelial progenitor cells for treating ischemic strokeR01NS102720 · NINDS · WRIGHT STATE UNIVERSITY · PI BIHL, JI CHEN · 2018 to 2022
$1.6M
NINDS NIH HHS R01 NS102720
6 · The paper itself

Abstract

Angiotensin-converting enzyme 2 (ACE2) is an emerging cardiovascular protective target that mediates the metabolism of angiotensin (Ang) II into Ang (1-7). Our group has demonstrated that ACE2 overexpression enhances the function of endothelial progenitor cells (EPCs). Here, we investigated whether ACE2-primed EPCs (ACE2-EPCs) can protect cerebral microvascular endothelial cells (ECs) against injury and dysfunction in an

Indexed as

Angiotensin-Converting Enzyme 2Cells, CulturedCell SurvivalCoculture TechniquesCulture Media, ConditionedCytokinesEndothelial CellsEndothelial Progenitor CellsExosomesHumansMembrane PotentialsMitochondriaParacrine CommunicationPeptidyl-Dipeptidase AReactive Oxygen SpeciesVascular Endothelial Growth Factor AACE2 protein, humanAngiotensin-Converting Enzyme 2Culture Media, ConditionedCytokinesPeptidyl-Dipeptidase AReactive Oxygen SpeciesVascular Endothelial Growth Factor A

Identifiers

PMID32051731
PMCPMC6995312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.