ArticleArchives of medical science : AMS2020
Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats.
Article in Archives of medical science : AMS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Benfotiamine promotes diabetic wound healing by modulating Trisk95 and reducing oxidative stress.Diabetology & metabolic syndrome · 2026Article
- The protective effects of sesamin on the ileum in superior mesenteric artery ischemia induced in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study.Journal of molecular histology · 2024Article
- Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity.Journal of molecular histology · 2022Article
- Protective effect of vitamin D on imidacloprid-induced testicular injury in rats.Archives of medical science : AMS · 2022Article
- Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease.Journal of the neurological sciences · 2021Review
- Irisin and Incretin Hormones: Similarities, Differences, and Implications in Type 2 Diabetes and Obesity.Biomolecules · 2021Review
- Part II. high-dose methotrexate with leucovorin rescue for severe COVID-19: An immune stabilization strategy for SARS-CoV-2 induced 'PANIC' attack.Journal of the neurological sciences · 2020Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMethotrexate (MTX) causes hepatotoxicity by producing oxidative stress. Benfotiamine and irisin have protective effects against oxidative stress. The aim of this study was to investigate the changes in irisin activity in the liver as a result of toxicity produced by MTX and the protective role of benfotiamine in the hepatotoxicity. MATERIAL AND
methodsRats were divided into 4 groups as follows: control, benfotiamine (50 mg/kg, oral gavage (o.g.), for 14 days), MTX (MTX 20 mg/kg intraperitoneally (i.p.) on day 1), MTX + benfotiamine (MTX 20 mg/kg (i.p.) on day 1, then 50 mg/kg (o.g.) benfotiamine for 14 days). Liver tissue was used to examine histopathological and immunohistochemical changes. Serum was used to look for oxidative stress markers (total antioxidant status (TAS) and total oxidant status (TOS)).
resultsAdministration of MTX caused a significant TOS increase and TAS decrease in the serum as compared to the control group. Immunohistochemically, irisin was significantly increased in immunoreactivity in the MTX group as compared to the control group (
conclusionsOur results showed that MTX caused an increase in the activity of irisin after producing toxicity in the liver. In addition, we found that benfotiamine was effective in preventing damage caused by MTX in the liver.
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