Evidence map›Paper›PMID 32051671›Full record

ArticleJournal of orthopaedics

Locally delivered minocycline microspheres do not impair osseointegration of titanium implants in a rat femur model.

Joshua A Shapiro, Samuel AbuMoussa, Christopher P Lindsay, Gabriel B Mason, Laurence E Dahners, Paul S Weinhold

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joshua A ShapiroDepartment of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA.
Samuel AbuMoussaDepartment of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA.
Christopher P LindsayDepartment of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA.
Gabriel B MasonDepartment of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA.
Laurence E DahnersDepartment of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA.
Paul S WeinholdDepartment of Orthopaedics, University of North Carolina, Chapel Hill, NC, USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
NCI NIH HHS P30 CA016086
6 · The paper itself

Abstract

backgroundThe purpose of this study was to determine whether intramedullary administration of extended-release minocycline microspheres would affect osseointegration.

methodsTwenty-two rats were randomized to minocycline or saline femoral intramedullary injection followed by implantation of titanium alloy rods. Following euthanasia at four-weeks, pushout testing was performed and bone-volume-fraction assessed.

resultsPushout strength was marginally greater in minocycline-treated implants (122.5 ± 39.1 N) compared to saline (96.9 ± 26.1 N) (P = 0.098). No difference was observed in energy to maximum load, mean stiffness, or peri-implant bone-volume-fraction (P > 0.05).

conclusionsPeri-implant minocycline administration did not impair implant fixation strength or peri-implant bone-volume, supporting its potential utility as an adjunct to intramedullary implants.

Indexed as

Bone volume fractionMinocyclineOsseointegrationPushout testingSprague-Dawley

Identifiers

PMID32051671
PMCPMC7005344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.