ArticleNature2020
Loss of p53 drives neuron reprogramming in head and neck cancer.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 269 papers.
0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed
39.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
269 citing papers in PubMed, 437 citations in OpenAlex.
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- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- LFPM inhibition of RING1-mediated p53Cell death and differentiation · 2026Article
- Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro-Ecological Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Understanding nerve-tumor interactions: From basic biology to therapeutic innovation.Genes & diseases · 2026Review
- microRNA-204 as a crucial cancer stem cell related miRNA inhibits stemness of gastric cancer by targeting CD44 and EPCAM.Journal of translational medicine · 2026Article
- Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma.Discover oncology · 2026Article
- The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.Marine drugs · 2026Review
- Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk.Chinese medical journal pulmonary and critical care medicine · 2026Review
- β-Adrenergic Signaling Promotes Anti-Tumor Immunity in TP53-mutant Oral Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cancer Neoaxonogenesis: Mechanisms and Factors Involved in the Recruitment of Peripheral Nerves by Cancer Tissue.International journal of molecular sciences · 2026Review
- The Neuroimmune Connectome: Understanding how the Peripheral Nervous System shapes Immunity.ImmunoHorizons · 2026Review
- Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1.Cancer research · 2026Article
209 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 3 institutions in 2 countries.
Moran Amit *Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mamit@mdanderson.org.
Hideaki Takahashi *Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mihnea Paul DragomirDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Antje LindemannDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Frederico O Gleber-NettoDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Curtis R PickeringDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Simone AnfossiDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abdullah A OsmanDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yu CaiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rong WangDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Erik KnutsenDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Masayoshi ShimizuDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cristina IvanDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xiayu RaoDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jing WangDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Deborah A SilvermanDepartment of Melanoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Samantha TamDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mei ZhaoDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Carlos CaulinDepartment of Otolaryngology, Head and Neck Surgery, University of Arizona, Tucson, AZ, USA.
Assaf ZingerRegenerative Medicine Program, Houston Methodist Research Institute, Houston, TX, USA.
Ennio TasciottiRegenerative Medicine Program, Houston Methodist Research Institute, Houston, TX, USA.
Patrick M DoughertyDepartment of Pain Medicine, Division of Anesthesiology, Critical Care, and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Adel El-NaggarDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
George A CalinDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. gcalin@mdanderson.org.
Jeffrey N MyersDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jmyers@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USHouston Methodist · USUniversity of Arizona Cancer Center
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MUPR/MDACC Partnership for Excellence in Cancer Research(Parent Grant U54 CA096297)U54CA096297 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Ilka C Rios · 2002 to 2026
$36.9MUPR/MDACC Partnership for Excellence in Cancer Research (Luis Segarra supplement)U54CA096300 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Larkin Strong · 2002 to 2026
$23.8MProgression of Metastasis of Oral Tongue CancerR01DE014613 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MYERS, JEFFREY NICHOLAS · 2003 to 2018
$5.4MNovel extra cellular RNA-based combinatorial RNA inhibition therapyUH3TR000943 · NCATS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., LOPEZ-BERESTEIN, GABRIEL · 2015 to 2017
$3.2MProtein-coding and non-coding RNA biomarkers for early detection of CLLR01CA182905 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABRUZZO, LYNNE V., CALIN, GEORGE A. · 2014 to 2018
$2.9MFunctional roles of GOF TP53 mutations in metastasis and immunosuppression of head and neck cancersR01DE030875 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jeffrey Nicholas Myers, Andrew Sikora · 2022 to 2026
$2.8MmiR-155 targeted therapeutics for precision medicine in lung cancerR01CA222007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., CRISTINI, VITTORIO · 2018 to 2022
$2.6MThe role of ENF loss, TLR4 and spinal plasticity in paclitaxel CIPNR01CA200263 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DOUGHERTY, PATRICK M · 2016 to 2020
$2.4MViral miRs and cellular miRs in sepsisR01GM122775 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., LUPU, FLOREA · 2018 to 2020
$1.1MThe Role of Mutant p53 in Regulating T-cell Immune Evasion in Pancreatic Adenocarcinoma and Other CancersF30CA228258 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SILVERMAN, DEBORAH ANN · 2019 to 2022
$100kNCATS NIH HHS UH3 TR000943NCI NIH HHS F30 CA228258NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA182905NCI NIH HHS R01 CA200263NCI NIH HHS R01 CA222007NCI NIH HHS U54 CA096297NCI NIH HHS U54 CA096300NIDCR NIH HHS R01 DE014613NIDCR NIH HHS R01 DE030875NIGMS NIH HHS R01 GM122775
Abstract
The solid tumour microenvironment includes nerve fibres that arise from the peripheral nervous system
Indexed as
Cell TransdifferentiationCellular ReprogrammingAdrenergic AntagonistsAdrenergic NeuronsAnimalsCell DivisionDisease Models, AnimalDisease ProgressionFemaleHumansMaleMiceMice, Inbred BALB CMicroRNAsMouth NeoplasmsNerve FibersAdrenergic AntagonistsMicroRNAsMIRN34 microRNA, humanReceptors, AdrenergicTP53 protein, humanTumor Suppressor Protein p53
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.