ArticleNature2020
Mechanical regulation of glycolysis via cytoskeleton architecture.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 339 papers.
0numbers the graph read from it
0cells of the map it votes in
339citing papers in PubMed
37.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
339 citing papers in PubMed, 581 citations in OpenAlex.
- 3D matrix stiffness drives energy metabolism to orchestrate stem cell osteogenesis via microtubule acetylation and mitochondrial dynamics.Bioactive materials · 2026Article
- Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- H3K18la in periodontal ligament fibroblasts regulates immune niches and alveolar bone remodeling under mechanical loads.International journal of oral science · 2026Article
- High-Density Type I Collagen Promotes IFN-γAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications.International journal of oral science · 2026Review
- Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow-Dependent Endothelial Activation and Atherogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Matrix stiffness drives HCC invasion and metastasis via interfering with TRIM21-mediated SCD1 ubiquitination.Oncogene · 2026Article
- Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function.bioRxiv : the preprint server for biology · 2026Article
- The oocyte-enriched metabolite serotonin alleviates cellular senescence and aging phenotypes in the mouse.The EMBO journal · 2026Article
- Suppression of Ciliogenesis Alleviates Cellular Senescence via AKT Signaling in Gingival Aging.Aging cell · 2026Article
- HMGA1 Lactylation-Mediated Regulation of the SP1/VEGFA Axis in Pathological Angiogenesis Under Diabetic Retinopathy.Diabetes · 2026Article
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- Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway.Oncogenesis · 2026Article
- Mechanisms of actin-binding proteins in glycolysis-cytoskeleton coupling.Journal of translational medicine · 2026Review
- Supercharged ferritin nanocages enable universal cytosolic protein delivery.Nature communications · 2026Article
- PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance.The Plant journal : for cell and molecular biology · 2026Review
- Mechanical forces of beating heart suppress cancer growth.Mechanobiology in medicine · 2026Article
- Nanoparticles reach metastatic tumours via enhanced permeability of adjacent vessels.Nature nanotechnology · 2026Article
- Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
279 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 5 institutions in 1 country.
Jin Suk ParkLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Christoph J BurckhardtLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. christoph.burckhardt@utsouthwestern.edu.
Rossana LazcanoDepartment of Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX, USA.
Luisa M SolisDepartment of Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX, USA.
Tadamoto IsogaiLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Linqing LiWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Christopher S ChenWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Boning GaoHamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, TX, USA.
John D MinnaHamon Center for Therapeutic Oncology, UT Southwestern Medical Center, Dallas, TX, USA.
Robert BachooAnnette G. Strauss Center for Neuro-Oncology, UT Southwestern Medical Center, Dallas, TX, USA.
Ralph J DeBerardinisChildren's Research Institute and Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.
Gaudenz DanuserLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. gaudenz.danuser@utsouthwestern.edu.
Southwestern Medical CenterThe University of Texas Southwestern Medical Center · USBoston University · USThe University of Texas MD Anderson Cancer Center · USSouthwestern Medical Center · US
Funding
UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V., MINNA, JOHN D. · 1996 to 2024
$57.4MUT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7MMetabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4MREGULATION OF ANGIOGENESIS BY MICROENVIRONMENTAL CUESR01EB000262 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHRISTOPHER S · 2002 to 2023
$6.2MEngineering Multicellular Tissue Structure, Function, and VascularizationR01EB008396 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI BHATIA, SANGEETA N., CHEN, CHRISTOPHER S · 2009 to 2018
$5.8MThe Mechanics of Actin-mediated Cell ProtrusionR01GM071868 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DANUSER, GAUDENZ · 2007 to 2020
$2.9MNCI NIH HHS P30 CA142543NCI NIH HHS P50 CA070907NCI NIH HHS R35 CA220449NIBIB NIH HHS R01 EB000262NIBIB NIH HHS R01 EB008396NIGMS NIH HHS R01 GM071868
Abstract
The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility
Indexed as
Cellular MicroenvironmentGlycolysisHardnessActinsActomyosinAnimalsBronchiCattleCell DifferentiationCell LineCytoskeletonEpithelial CellsGlucoseHumansNeoplasmsPhosphofructokinasesActinsActomyosinGlucosePhosphofructokinasesProteasome Endopeptidase ComplexRibonucleoproteinsSS-A AntigenUbiquitin-Protein Ligases
Identifiers
What OpenQuestion holds
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LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.