ArticleNature biomedical engineering2020
Reconfigurable nanophotonic silicon probes for sub-millisecond deep-brain optical stimulation.
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 173 citations in OpenAlex.
- Field-Programmable Mobile Magneto-Photonic Metaparticles for Active Light Manipulation and Steering.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.Nature methods · 2026Article
- Hybrid Integration of InGaN Lasers in a Foundry-Fabricated Visible-Light Photonics Platform.Nanophotonics (Berlin, Germany) · 2026Article
- Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery.Microsystems & nanoengineering · 2026Article
- Electrically Tunable Optofluidic Metasurface.ACS nano · 2026Article
- NEO-PGA: Nonvolatile electro-optically programmable gate array.Science advances · 2026Article
- Focusing optical phased array for tissue interrogation with improved side-lobe suppression and simplified beam steering.Biomedical optics express · 2026Article
- Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
- Foundry-fabricated dual-color nanophotonic neural probes for photostimulation and electrophysiological recording.Neurophotonics · 2025Article
- Electrochemically mutable soft metasurfaces.Nature materials · 2025Article
- Article
- In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025Article
- Implantable silicon neural probes with nanophotonic phased arrays for single-lobe beam steering.Communications engineering · 2024Article
- A thin film lithium niobate near-infrared platform for multiplexing quantum nodes.Nature communications · 2024Article
- Implantable photonic nano-modulators open perspectives for advanced optical interfaces with deep brain areas.Neurophotonics · 2024Article
- Emerging technologies toward the integration of multiple functionalities on non-planar implantable neurophotonics probes.Neurophotonics · 2024Article
- Implantable photonic neural probes with out-of-plane focusing grating emitters.Scientific reports · 2024Article
- Nonvolatile optical phase shift in ferroelectric hafnium zirconium oxide.Nature communications · 2024Article
- Mechanically-flexible wafer-scale integrated-photonics fabrication platform.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of nanophotonics to rapidly and precisely reconfigure light beams for the optical stimulation of neurons in vivo has remained elusive. Here we report the design and fabrication of an implantable silicon-based probe that can switch and route multiple optical beams to stimulate identified sets of neurons across cortical layers and simultaneously record the produced spike patterns. Each switch in the device consists of a silicon nitride waveguide structure that can be rapidly (<20 μs) reconfigured by electrically tuning the phase of light. By using an eight-beam probe, we show in anaesthetized mice that small groups of single neurons can be independently stimulated to produce multineuron spike patterns at sub-millisecond precision. We also show that a probe integrating co-fabricated electrical recording sites can simultaneously optically stimulate and electrically measure deep-brain neural activity. The technology is scalable, and it allows for beam focusing and steering and for structured illumination via beam shaping. The high-bandwidth optical-stimulation capacity of the device might facilitate the probing of the spatiotemporal neural codes underlying behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.