Evidence map›Paper›PMID 32051567›Full record

ReviewNature reviews. Nephrology2020

Long-term outcomes of acute kidney injury and strategies for improved care.

Matthew T James, Meha Bhatt, Neesh Pannu, Marcello Tonelli

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 7 pooled it
21.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 7 syntheses or guidelines pooled it, 308 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
  4. Pooled it
  5. Pooled it
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  7. Pooled it
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Social Determinants of Health and ESKD among Survivors of Critical Illness and Acute Kidney Injury.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Observational
  16. Article
  17. Article
  18. Review
  19. Caveolin-1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  20. Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Matthew T JamesDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. mjames@ucalgary.ca.ORCID http://orcid.org/0000-0002-1876-3917
Meha BhattDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0002-1165-0493
Neesh PannuDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Marcello TonelliDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
University of Calgary · CAUniversity of Alberta · CA

Funding

CIHR
6 · The paper itself

Abstract

Acute kidney injury (AKI), once viewed predominantly as a self-limited and reversible condition, is now recognized as a growing problem associated with significant risks of adverse long-term health outcomes. Many cohort studies have established important relationships between AKI and subsequent risks of recurrent AKI, hospital re-admission, morbidity and mortality from cardiovascular disease and cancer, as well as the development of chronic kidney disease and end-stage kidney disease. In both high-income countries (HICs) and low-income or middle-income countries (LMICs), several challenges exist in providing high-quality, patient-centered care following AKI. Despite advances in our understanding about the long-term risks following AKI, large gaps in knowledge remain about effective interventions that can improve the outcomes of patients. Therapies for high blood pressure, glycaemic control (for patients with diabetes), renin-angiotensin inhibition and statins might be important in improving long-term cardiovascular and kidney outcomes after AKI. Novel strategies that incorporate risk stratification approaches, educational interventions and new models of ambulatory care following AKI have been described, and some of these are now being implemented and evaluated in clinical studies in HICs. Care for AKI in LMICs must overcome additional barriers due to limited resources for diagnosis and management.

Indexed as

Cause of DeathDisease ManagementAcute Kidney InjuryDisease ProgressionFemaleHospitalizationHumansKidney Failure, ChronicMalePrognosisRenal Insufficiency, ChronicRisk AssessmentSeverity of Illness IndexSurvival AnalysisTime Factors

Identifiers

PMID32051567
OpenAlexW3005876467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.