Observational studyScientific reports2020
Functional MRI Mapping of Human Meniscus Functionality and its Relation to Degeneration.
Observational study in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Longitudinal Quantitative Mapping of Meniscal Morphological and Signal Intensity Differences After ACL Surgery.The American journal of sports medicine · 2026Article
- Histological analysis of age-related degeneration in human female and male knee cartilage and meniscus.Osteoarthritis and cartilage open · 2026Article
- Vascularization Characteristics of the Different Meniscal Layers: Three-Dimensional Assessment With Micro-CT.Orthopaedic journal of sports medicine · 2025Article
- Quantitative bone marrow lesion, meniscus, and synovitis measurement: current status.Skeletal radiology · 2023Review
- Periodical assessment of four horns of knee meniscus using MR T2 mapping imaging in volunteers before and after amateur marathons.Scientific reports · 2022Article
- Chemical Exchange Saturation Transfer for Lactate-Weighted Imaging at 3 T MRI: Comprehensive In Silico, In Vitro, In Situ, and In Vivo Evaluations.Tomography (Ann Arbor, Mich.) · 2022Article
- Apelin Alleviates Meniscus Endothelial Cell Apoptosis in Osteoarthritis.Disease markers · 2022Article
- In-Situ Cartilage Functionality Assessment Based on Advanced MRI Techniques and Precise Compartmental Knee Joint Loading through Varus and Valgus Stress.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meniscus pathology may promote early osteoarthritis. This study assessed human meniscus functionality (i.e. its response to loading) ex vivo based on quantitative T1, T1ρ, and T2 mapping as a function of histological degeneration and loading. Forty-five meniscus samples of variable degeneration were harvested from the lateral meniscus body region of 45 patients during total knee arthroplasties. Samples underwent serial mapping on a 3.0-T MRI scanner (Achieva, Philips) using a force-controlled and torque-inducing compressive loading device. Samples were measured at three loading positions, i.e. unloaded, loaded to 2 bar (compression force 37 N) and 4 bar (69 N). Histology (Pauli classification) and biomechanics (Elastic Modulus) served as references. Based on histology, samples were trichotomized as grossly intact (n = 14), mildly degenerative (n = 16), and moderate-to-severely degenerative (n = 15) and analyzed using appropriate parametric and non-parametric tests. For T1, we found loading-induced decreases in all samples, irrespective of degeneration. For T1ρ, zonal increases in intact (apex) and decreases in degenerative samples (base) were found, while for T2, changes were ambiguous. In conclusion, force-controlled loading and serial MR imaging reveal response-to-loading patterns in meniscus. Zonal T1ρ response-to-loading patterns are most promising in differentiating degeneration, while T1 and T2 aren't clearly related to degeneration.and may provide an imaging-based indication of functional tissue properties.
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