Evidence map›Paper›PMID 32051524›Full record

ArticleScientific reports2020

In vitro modeling of dendritic atrophy in Rett syndrome: determinants for phenotypic drug screening in neurodevelopmental disorders.

Elisa Nerli, Ottavia Maria Roggero, Gabriele Baj, Enrico Tongiorgi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Oral Manifestations of Rett Syndrome-A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  2. Article
  3. Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elisa NerliBRAIN Center for Neuroscience, Department of Life Sciences, University of Trieste, 34127, Trieste, Italy.
Ottavia Maria RoggeroBRAIN Center for Neuroscience, Department of Life Sciences, University of Trieste, 34127, Trieste, Italy.
Gabriele BajBRAIN Center for Neuroscience, Department of Life Sciences, University of Trieste, 34127, Trieste, Italy.ORCID http://orcid.org/0000-0002-2625-9454
Enrico TongiorgiBRAIN Center for Neuroscience, Department of Life Sciences, University of Trieste, 34127, Trieste, Italy. tongi@units.it.ORCID http://orcid.org/0000-0003-0485-0603
University of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic atrophy, defined as the reduction in complexity of the neuronal arborization, is a hallmark of several neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, affecting 1:10,000 girls worldwide, is mainly caused by mutations in the MECP2 gene and has no cure. We describe here an in vitro model of dendritic atrophy in Mecp2

Indexed as

PhenotypeAnimalsBrain-Derived Neurotrophic FactorCells, CulturedDendritesDrug Evaluation, PreclinicalHippocampusMethyl-CpG-Binding Protein 2MiceMice, Inbred C57BLMirtazapineNeuroprotective AgentsRett SyndromeBrain-Derived Neurotrophic FactorMecp2 protein, mouseMethyl-CpG-Binding Protein 2MirtazapineNeuroprotective Agents

Identifiers

PMID32051524
PMCPMC7016139
OpenAlexW3006322626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.