ArticleScientific reports2020
MorbiNet: multimorbidity networks in adult general population. Analysis of type 2 diabetes mellitus comorbidity.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Longitudinal Patterns of Within- and Cross-Domain Multimorbidity Across Physical, Psychological, and Cognitive Conditions in China and the United States: The Role of Socioeconomic and Healthcare Inequalities.Healthcare (Basel, Switzerland) · 2026Article
- Multimorbidity Clusters Among People Aged 65 Years and Over in Australia: A Nationwide Cross-Sectional Data Linkage Study.The Medical journal of Australia · 2026Article
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- Mapping sex-based multimorbidity networks in type 1 diabetes: a real-world study from Shanghai.Frontiers in endocrinology · 2026Article
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- Multiple long-term conditions as the next transition in the global diabetes epidemic.Communications medicine · 2025Review
- Network Analysis of Legg-Calve-Perthes Disease and Its Comorbidities.Journal of clinical medicine · 2025Article
- Predictive factors and risk model for depression in patients with type 2 diabetes mellitus: a comprehensive analysis of comorbidities and clinical indicators.Frontiers in endocrinology · 2025Article
- Federated multimodal AI for precision-equitable diabetes care.Frontiers in digital health · 2025Review
- Number of chronic diseases and cognitive function among the elderly in China: a moderated mediation model.Frontiers in psychology · 2025Article
- Disease Network-Based Approaches to Study Comorbidity in Heart Failure: Current State and Future Perspectives.Current heart failure reports · 2024Review
- PheMIME: an interactive web app and knowledge base for phenome-wide, multi-institutional multimorbidity analysis.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Choices of measures of association affect the visualisation and composition of the multimorbidity networks.BMC medical research methodology · 2024Article
- Depressive symptom mediates the association between the number of chronic diseases and cognitive impairment: a multi-center cross-sectional study based on community older adults.Frontiers in psychiatry · 2024Article
- Comorbidity patterns in cardiovascular diseases: the role of life-stage and socioeconomic status.Frontiers in cardiovascular medicine · 2024Article
- Progression and trajectory network of age-related functional impairments and their combined associations with mortality.iScience · 2023Article
- A network-based study reveals multimorbidity patterns in people with type 2 diabetes.iScience · 2023Article
- PheMIME: An Interactive Web App and Knowledge Base for Phenome-Wide, Multi-Institutional Multimorbidity Analysis.medRxiv : the preprint server for health sciences · 2023Article
- A network medicine approach to study comorbidities in heart failure with preserved ejection fraction.BMC medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multimorbidity has great impact on health care. We constructed multimorbidity networks in the general population, extracted subnets focused on common chronic conditions and analysed type 2 diabetes mellitus (T2DM) comorbidity network. We used electronic records from 3,135,948 adult people in Catalonia, Spain (539,909 with T2DM), with at least 2 coexistent chronic conditions within the study period (2006-2017). We constructed networks from odds-ratio estimates adjusted by age and sex and considered connections with OR > 1.2 and p-value < 1e-5. Directed networks and trajectories were derived from temporal associations. Interactive networks are freely available in a website with the option to customize characteristics and subnets. The more connected conditions in T2DM undirected network were: complicated hypertension and atherosclerosis/peripheral vascular disease (degree: 32), cholecystitis/cholelithiasis, retinopathy and peripheral neuritis/neuropathy (degree: 31). T2DM has moderate number of connections and centrality but is associated with conditions with high scores in the multimorbidity network (neuropathy, anaemia and digestive diseases), and severe conditions with poor prognosis. The strongest associations from T2DM directed networks were to retinopathy (OR: 23.8), glomerulonephritis/nephrosis (OR: 3.4), peripheral neuritis/neuropathy (OR: 2.7) and pancreas cancer (OR: 2.4). Temporal associations showed the relevance of retinopathy in the progression to complicated hypertension, cerebrovascular disease, ischemic heart disease and organ failure.
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