Evidence map›Paper›PMID 32051464›Full record

ArticleScientific reports2020

Dysregulated metabolic pathways in age-related macular degeneration.

Meng Zhang, Nisi Jiang, Yi Chu, Olga Postnikova, Rency Varghese, Anelia Horvath, Amrita K Cheema, Nady Golestaneh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

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  15. Exploiting autophagy and related pathways: pioneering new horizons in cataract therapy.Apoptosis : an international journal on programmed cell death · 2025
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Meng ZhangDepartment of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Nisi JiangDepartment of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Yi ChuDepartment of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Olga PostnikovaLaboratory of Retinal Cell & Molecular Biology (HNW28), NIH/NEI, Bethesda, MD, 20814, USA.
Rency VargheseDepartment of Oncology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Anelia HorvathDepartment of Pharmacology and Physiology, Department of Biochemistry and Molecular Medicine, George Washington University, Washington, DC, 20037, USA.
Amrita K CheemaDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, 20057, USA.
Nady GolestanehDepartment of Ophthalmology, Georgetown University Medical Center, Washington, DC, 20057, USA. ncg8@georgetown.edu.
Georgetown University Medical Center · USGeorgetown University · USGeorge Washington University · USNational Institutes of Health · US

Funding

AMPK/SIRT1/PGC-1α, a critical pathway in dry AMDR01EY028917 · NEI · GEORGETOWN UNIVERSITY · PI GOLESTANEH, NADY · 2019 to 2023
$1.9M
BrightFocus Foundation (BrightFocus) M2014039NEI NIH HHS R01 EY028917
6 · The paper itself

Abstract

Age-related macular degeneration is a major cause of vision impairment in the Western world among people of 55 years and older. Recently we have shown that autophagy is dysfunctional in the retinal pigment epithelium (RPE) of the AMD donor eyes (AMD RPE). We also showed increased reactive oxygen (ROS) production, increased cytoplasmic glycogen accumulation, mitochondrial dysfunction and disintegration, and enlarged and annular LAMP-1-positive organelles in AMD RPE. However, the underlying mechanisms inducing these abnormalities remain to be elucidated. Here, by performing a comprehensive study, we show increased PAPR2 expression, deceased NAD+, and SIRT1, increased PGC-1α acetylation (inactive form), lower AMPK activity, and overactive mTOR pathway in AMD RPE as compared to normal RPE. Metabolomics and lipidomics revealed dysregulated metabolites in AMD RPE as compared to normal RPE, including glycerophospholipid metabolism, involved in autophagy, lipid, and protein metabolisms, glutathione, guanosine, and L-glutamic acid, which are implicated in protection against oxidative stress and neurotoxicity, further supporting our observations. Our data show dysregulated metabolic pathways as important contributors to AMD pathophysiology, and facilitate the development of new treatment strategies for this debilitating disease of the visual system.

Indexed as

Metabolic Networks and PathwaysAMP-Activated Protein Kinase KinasesFemaleGlycogenHumansLipid MetabolismMacular DegenerationMaleMetabolomeMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPoly(ADP-ribose) PolymerasesProtein KinasesReactive Oxygen SpeciesRetinal Pigment EpitheliumSirtuin 1AMP-Activated Protein Kinase KinasesGlycogenPARP2 protein, humanPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPoly(ADP-ribose) PolymerasesProtein KinasesReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1

Identifiers

PMID32051464
PMCPMC7016007
OpenAlexW3005716150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.