Evidence map›Paper›PMID 32051381›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment.

Kei Nakashima, Koichi Saruwatari, Ryo Sato, Kosuke Imamura, Ikko Kajihara, Satoshi Fukushima, Tetsuo Saito, Shiho Ishizuka, Daisuke Tamanoi, Takayuki Jodai and 7 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Radiation recall dermatitis in cancer patients previously undergoing radiotherapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  2. Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR).Journal of medical imaging and radiation oncology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Kei NakashimaDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Koichi SaruwatariDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Ryo SatoDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Kosuke ImamuraDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Ikko KajiharaDepartment of Dermatology and Plastic Surgery, Kumamoto University Hospital, Japan.
Satoshi FukushimaDepartment of Dermatology and Plastic Surgery, Kumamoto University Hospital, Japan.
Tetsuo SaitoDepartment of Radiation Oncology, Kumamoto University Hospital, Japan.
Shiho IshizukaDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Daisuke TamanoiDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Takayuki JodaiDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Shohei HamadaDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Yusuke TomitaDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Sho SaekiDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Hidenori IchiyasuDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Natsuo OyaDepartment of Radiation Oncology, Kumamoto University Hospital, Japan.
Hironobu IhnDepartment of Dermatology and Plastic Surgery, Kumamoto University Hospital, Japan.
Takuro SakagamiDepartment of Respiratory Medicine, Kumamoto University Hospital, Japan.
Kumamoto University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation recall dermatitis (RRD) is an inflammatory reaction that occurs at previously irradiated skin regions after drug administration. We herein report a patient with non-small-cell lung cancer treated previously with thoracic radiotherapy who developed severe RRD induced by atezolizumab [anti-programmed death 1 ligand 1 (PD-L1) antibody]. Immunohistochemistry of the skin biopsy showed dermatitis with infiltration of CD8+ lymphocytes, suggesting that atezolizumab might provoke an immune-related inflammatory reaction at previously irradiated skin regions. When administering anti-PD-L1 antibody to patients who have undergone radiotherapy previously, physicians should carefully monitor the irradiated skin for the potential occurrence of RRD.

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic AgentsCarcinoma, Non-Small-Cell LungCombined Modality TherapyDiagnosis, DifferentialHumansLung NeoplasmsMaleMiddle AgedRadiodermatitisSeverity of Illness IndexAntibodies, Monoclonal, HumanizedAntineoplastic Agentsatezolizumabatezolizumabnon-small cell lung cancerradiation recall dermatitis

Identifiers

PMID32051381
PMCPMC7270770
OpenAlexW3006004917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.