Evidence map›Paper›PMID 32051379›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Clinical Application of Next-generation Sequencing for the Diagnosis of Lung Squamous Cell Carcinoma: Is It Primary or Secondary?

Hiroaki Aizawa, Takahiro Karasaki, Kazuhiro Nagayama, Aya Shinozaki-Ushiku, Hiroyuki Aburatani, Hiroyuki Mano, Jun Nakajima

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroaki AizawaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Japan.
Takahiro KarasakiDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Japan.
Kazuhiro NagayamaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Japan.
Aya Shinozaki-UshikuDepartment of Pathology, The University of Tokyo Graduate School of Medicine, Japan.
Hiroyuki AburataniGenome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Japan.
Hiroyuki ManoDivision of Cellular Signaling, National Cancer Center Research Institute, Japan.
Jun NakajimaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 80-year-old man with a history of cutaneous squamous cell carcinoma (SCC) was referred to our department for a solitary lung nodule. The nodule was surgically resected and diagnosed as SCC. Because the lung lesion and a previous skin lesion showed similar histological findings, the origin of the lung tumor was uncertain. Next-generation sequencing using a targeted driver oncogene panel was applied for the further examination. The lung lesion was diagnosed as primary lung SCC, as the two tumors possessed distinct somatic mutations in TP53. Recent advances in clinical sequencing have enabled us to obtain an accurate diagnosis in pathologically challenging cases.

Indexed as

Aged, 80 and overCarcinoma, Squamous CellDiagnosis, DifferentialHigh-Throughput Nucleotide SequencingHumansLung NeoplasmsMaleMutationTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53massively parallel sequencingnext-generation sequencingsomatic mutationsquamous cell carcinoma

Identifiers

PMID32051379
PMCPMC7303454

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.