ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
The Contribution of AMPA and NMDA Receptors to Persistent Firing in the Dorsolateral Prefrontal Cortex in Working Memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
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- Hippocampal and prefrontal GABA and glutamate concentration contribute to component processes of working memory in aging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Effects of Ketamine on Frontoparietal Interactions in a Rule-Based Antisaccade Task in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Electroencephalogram criticality in cognitive impairment: a monitoring biomarker?Cognitive neurodynamics · 2024Article
- The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions.iScience · 2024Article
- Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex.Brain sciences · 2024Review
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- Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder.Psychiatry and clinical neurosciences · 2022Article
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- 50 years of mnemonic persistent activity: quo vadis?Trends in neurosciences · 2021Review
- Contribution of Ionotropic Glutamatergic Receptors to Excitability and Attentional Signals in Macaque Frontal Eye Field.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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- Using rat operant delayed match-to-sample task to identify neural substrates recruited with increased working memory load.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Regional brain gray matter volume in world-class artistic gymnasts.The journal of physiological sciences : JPS · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many tasks demand that information is kept online for a few seconds before it is used to guide behavior. The information is kept in working memory as the persistent firing of neurons encoding the memorized information. The neural mechanisms responsible for persistent activity are not yet well understood. Theories attribute an important role to ionotropic glutamate receptors, and it has been suggested that NMDARs are particularly important for persistent firing because they exhibit long time constants. Ionotropic AMPARs have shorter time constants and have been suggested to play a smaller role in working memory. Here we compared the contribution of AMPARs and NMDARs to persistent firing in the dlPFC of male macaque monkeys performing a delayed saccade to a memorized spatial location. We used iontophoresis to eject small amounts of glutamate receptor antagonists, aiming to perturb, but not abolish, neuronal activity. We found that both AMPARs and NMDARs contributed to persistent activity. Blockers of the NMDARs decreased persistent firing associated with the memory of the neuron's preferred spatial location but had comparatively little effect on the representation of the antipreferred location. They therefore decreased the information conveyed by persistent firing about the memorized location. In contrast, AMPAR blockers decreased activity elicited by the memory of both the preferred and antipreferred location, with a smaller effect on the information conveyed by persistent activity. Our results provide new insights into the contribution of AMPARs and NMDARs to persistent activity during working memory tasks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.