Evidence map›Paper›PMID 32051279›Full record

ArticleJournal of virology2020

Next-Generation Sequencing in a Direct Model of HIV Infection Reveals Important Parallels to and Differences from

Marilia Rita Pinzone, Maria Paola Bertuccio, D Jake VanBelzen, Ryan Zurakowski, Una O'Doherty

Abstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marilia Rita PinzoneDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Maria Paola BertuccioDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
D Jake VanBelzenDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ryan ZurakowskiDelaware Biotechnology Institute, University of Delaware, Newark, Delaware, USA.
Una O'DohertyDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA unao@pennmedicine.upenn.edu.

Funding

BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
Determinants of reservoir contraction and expansion in vivo, ex vivo, and in vitroR37AI150556 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Una T O'Doherty · 2020 to 2026
$4.2M
A FAST Assay to Quantify HIV ReservoirsR01AI120011 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI O'DOHERTY, UNA T, SAMBUCETTI, LIDIA C · 2015 to 2019
$3.1M
Unveiling the chromosomal address of intact HIV clones to provide insights into persistenceR21AI143564 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI O'DOHERTY, UNA T · 2019 to 2020
$457k
An ex vivo model to predict outcomes and probe mechanism of anti-reservoir agentsR21AI116216 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI O'DOHERTY, UNA T · 2014 to 2015
$440k
Evidence of cryptic replication in dolutegravir intensification dataR03AI136710 · NIAID · UNIVERSITY OF DELAWARE · PI ZURAKOWSKI, RYAN M · 2018 to 2019
$155k
NIAID NIH HHS R01 AI120011NIAID NIH HHS R03 AI136710NIAID NIH HHS R21 AI116216NIAID NIH HHS R21 AI143564NIAID NIH HHS R37 AI150556NIAID NIH HHS UM1 AI126617
6 · The paper itself

Abstract

Next-generation sequencing (NGS) represents a powerful tool to unravel the genetic make-up of the HIV reservoir, but limited data exist on its use

Indexed as

CD4-Positive T-LymphocytesDisease ReservoirsDNA, ViralHigh-Throughput Nucleotide SequencingHIV-1HIV InfectionsHumansProvirusesVirus IntegrationVirus LatencyVirus ReplicationDNA, ViralHIVlatencyNGSreservoirresting cellssequencing

Identifiers

PMID32051279
PMCPMC7163122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.